Progress and challenges in protein structure prediction

@article{citeulike:2902291, abstract = {Depending on whether similar structures are found in the PDB library, the protein structure prediction can be categorized into template-based modeling and free modeling. Although threading is an efficient tool to detect the structural analogs, the advancements in methodology development have come to a steady state. Encouraging progress is observed in structure refinement which aims at drawing template structures closer to the native; this has been mainly driven by the use of multiple structure templates and the development of hybrid knowledge-based and physics-based force fields. For free modeling, exciting examples have been witnessed in folding small proteins to atomic resolutions. However, predicting structures for proteins larger than 150 residues still remains a challenge, with bottlenecks from both force field and conformational search.}, author = {Zhang, Yang }, booktitle = {Nucleic acids / Sequences and topology}, citeulike-article-id = {2902291}, doi = {http://dx.doi.org/10.1016/j.sbi.2008.02.004}, journal = {Current Opinion in Structural Biology}, keywords = {prediction, protein, structure}, month = {June}, number = {3}, pages = {342--348}, posted-at = {2008-06-27 03:37:25}, priority = {2}, title = {Progress and challenges in protein structure prediction}, url = {http://dx.doi.org/10.1016/j.sbi.2008.02.004}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:2902291 L3 - citeulike-article-id:2902291 TI - Progress and challenges in protein structure prediction T2 - Nucleic acids / Sequences and topology JF - Current Opinion in Structural Biology VL - 18 IS - 3 SP - 342 EP - 348 N2 - Depending on whether similar structures are found in the PDB library, the protein structure prediction can be categorized into template-based modeling and free modeling. Although threading is an efficient tool to detect the structural analogs, the advancements in methodology development have come to a steady state. Encouraging progress is observed in structure refinement which aims at drawing template structures closer to the native; this has been mainly driven by the use of multiple structure templates and the development of hybrid knowledge-based and physics-based force fields. For free modeling, exciting examples have been witnessed in folding small proteins to atomic resolutions. However, predicting structures for proteins larger than 150 residues still remains a challenge, with bottlenecks from both force field and conformational search. KW - prediction KW - protein KW - structure AU - Zhang, Yang PY - 2008/06// UR - http://dx.doi.org/10.1016/j.sbi.2008.02.004 ER -