The Protein Folding Problem

by: Ken A Dill, Banu S Ozkan, Scott M Shell, Thomas R Weikl

Annual Review of Biophysics, Vol. 37, No. 1. (2008), pp. 289-316.

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Abstract

The protein folding problem consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and moving toward successful applications. The structures of small proteins are now often well predicted by computer methods. And, there is now a testable explanation for how a protein can fold so quickly: A protein solves its large global optimization problem as a series of smaller local optimization problems, growing and assembling the native structure from peptide fragments, local structures first.

@article{citeulike:2770255, abstract = {The protein folding problem consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and moving toward successful applications. The structures of small proteins are now often well predicted by computer methods. And, there is now a testable explanation for how a protein can fold so quickly: A protein solves its large global optimization problem as a series of smaller local optimization problems, growing and assembling the native structure from peptide fragments, local structures first.}, author = {Dill, Ken A. and Ozkan, Banu S. and Shell, Scott M. and Weikl, Thomas R. }, citeulike-article-id = {2770255}, doi = {http://dx.doi.org/10.1146/annurev.biophys.37.092707.153558}, journal = {Annual Review of Biophysics}, keywords = {folding, protein}, number = {1}, pages = {289--316}, posted-at = {2008-05-08 09:53:48}, priority = {2}, title = {The Protein Folding Problem}, url = {http://dx.doi.org/10.1146/annurev.biophys.37.092707.153558}, volume = {37}, year = {2008} }

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TY - JOUR ID - citeulike:2770255 L3 - citeulike-article-id:2770255 TI - The Protein Folding Problem JF - Annual Review of Biophysics VL - 37 IS - 1 SP - 289 EP - 316 N2 - The protein folding problem consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and moving toward successful applications. The structures of small proteins are now often well predicted by computer methods. And, there is now a testable explanation for how a protein can fold so quickly: A protein solves its large global optimization problem as a series of smaller local optimization problems, growing and assembling the native structure from peptide fragments, local structures first. KW - folding KW - protein AU - Dill, Ken AU - Ozkan, Banu AU - Shell, Scott AU - Weikl, Thomas PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.biophys.37.092707.153558 ER -

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