Structural Principles from Large RNAs

@article{citeulike:2500316, abstract = {Since the year 2000 a number of large RNA three-dimensional structures have been determined by X-ray crystallography. Structures composed of more than 100 nucleotide residues include the signal recognition particle RNA, group I intron, the GlmS ribozyme, RNAseP RNA, and ribosomal RNAs from Haloarcula morismortui, Escherichia coli, Thermus thermophilus, and Deinococcus radiodurans. These large RNAs are constructed from the same secondary and tertiary structural motifs identified in smaller RNAs but appear to have a larger organizational architecture. They are dominated by long continuous interhelical base stacking, tend to segregate into domains, and are planar in overall shape as opposed to their globular protein counterparts. These findings have consequences in RNA folding, intermolecular interaction, and packing, in addition to studies of design and engineering and structure prediction. Expected final online publication date for the Annual Review of Biophysics Volume 37 is May 05, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, author = {Holbrook, Stephen R. }, citeulike-article-id = {2500316}, doi = {http://dx.doi.org/10.1146/annurev.biophys.36.040306.132755}, journal = {Annual Review of Biophysics}, keywords = {rna, secondary, structure}, number = {1}, posted-at = {2008-05-08 09:57:07}, priority = {5}, title = {Structural Principles from Large RNAs}, url = {http://dx.doi.org/10.1146/annurev.biophys.36.040306.132755}, volume = {37}, year = {2008} }

TY - JOUR ID - citeulike:2500316 L3 - citeulike-article-id:2500316 TI - Structural Principles from Large RNAs JF - Annual Review of Biophysics VL - 37 IS - 1 N2 - Since the year 2000 a number of large RNA three-dimensional structures have been determined by X-ray crystallography. Structures composed of more than 100 nucleotide residues include the signal recognition particle RNA, group I intron, the GlmS ribozyme, RNAseP RNA, and ribosomal RNAs from Haloarcula morismortui, Escherichia coli, Thermus thermophilus, and Deinococcus radiodurans. These large RNAs are constructed from the same secondary and tertiary structural motifs identified in smaller RNAs but appear to have a larger organizational architecture. They are dominated by long continuous interhelical base stacking, tend to segregate into domains, and are planar in overall shape as opposed to their globular protein counterparts. These findings have consequences in RNA folding, intermolecular interaction, and packing, in addition to studies of design and engineering and structure prediction. Expected final online publication date for the Annual Review of Biophysics Volume 37 is May 05, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - rna KW - secondary KW - structure AU - Holbrook, Stephen PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.biophys.36.040306.132755 ER -