Evolutionary plasticity of developmental gene regulatory network architecture

@article{citeulike:2000868, abstract = {Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for embryogenesis in these animals, we discovered an almost perfectly conserved five-gene network subcircuit required for endoderm specification. We show here that the GRN structure upstream and downstream of the conserved network kernel has, by contrast, diverged extensively. Mesoderm specification is accomplished quite differently; the DeltaNotch signaling system is used in radically distinct ways; and various regulatory genes have been coopted to different functions. The conservation of the conserved kernel is thus the more remarkable. The results indicate types of network linkage subject to evolutionary change. An emergent theme is that subcircuit design may be preserved even while the identity of genes performing given roles changes because of alteration in their cis-regulatory control systems. 10.1073/pnas.0709994104}, author = {Hinman, Veronica F. and Davidson, Eric H. }, citeulike-article-id = {2000868}, doi = {http://dx.doi.org/10.1073/pnas.0709994104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {architecture, evolution, gene, network, regulatory}, month = {November}, pages = {0709994104+}, posted-at = {2007-12-05 10:58:17}, priority = {2}, title = {Evolutionary plasticity of developmental gene regulatory network architecture}, url = {http://dx.doi.org/10.1073/pnas.0709994104}, year = {2007} }

TY - JOUR ID - citeulike:2000868 L3 - citeulike-article-id:2000868 TI - Evolutionary plasticity of developmental gene regulatory network architecture JF - Proceedings of the National Academy of Sciences SP - 0709994104 N2 - Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for embryogenesis in these animals, we discovered an almost perfectly conserved five-gene network subcircuit required for endoderm specification. We show here that the GRN structure upstream and downstream of the conserved network kernel has, by contrast, diverged extensively. Mesoderm specification is accomplished quite differently; the DeltaNotch signaling system is used in radically distinct ways; and various regulatory genes have been coopted to different functions. The conservation of the conserved kernel is thus the more remarkable. The results indicate types of network linkage subject to evolutionary change. An emergent theme is that subcircuit design may be preserved even while the identity of genes performing given roles changes because of alteration in their cis-regulatory control systems. 10.1073/pnas.0709994104 KW - architecture KW - evolution KW - gene KW - network KW - regulatory AU - Hinman, Veronica AU - Davidson, Eric PY - 2007/11/27/ UR - http://dx.doi.org/10.1073/pnas.0709994104 ER -