Adaptive Mutations in Bacteria: High Rate and Small Effects

by: Lilia Perfeito, Lisete Fernandes, Catarina Mota, Isabel Gordo

Science, Vol. 317, No. 5839. (10 August 2007), pp. 813-815.

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Abstract

Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 105 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity. 10.1126/science.1142284

@article{citeulike:1561465, abstract = {Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 105 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1\%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity. 10.1126/science.1142284}, author = {Perfeito, Lilia and Fernandes, Lisete and Mota, Catarina and Gordo, Isabel }, citeulike-article-id = {1561465}, doi = {http://dx.doi.org/10.1126/science.1142284}, journal = {Science}, keywords = {bacterial, genome, mutation}, month = {August}, number = {5839}, pages = {813--815}, posted-at = {2007-08-15 03:22:01}, priority = {1}, title = {Adaptive Mutations in Bacteria: High Rate and Small Effects}, url = {http://dx.doi.org/10.1126/science.1142284}, volume = {317}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1561465 L3 - citeulike-article-id:1561465 TI - Adaptive Mutations in Bacteria: High Rate and Small Effects JF - Science VL - 317 IS - 5839 SP - 813 EP - 815 N2 - Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 105 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity. 10.1126/science.1142284 KW - bacterial KW - genome KW - mutation AU - Perfeito, Lilia AU - Fernandes, Lisete AU - Mota, Catarina AU - Gordo, Isabel PY - 2007/08/10/ UR - http://dx.doi.org/10.1126/science.1142284 ER -

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