Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species.

@article{citeulike:1123346, abstract = {A major challenge in comparative genomics is to understand how phenotypic differences between species are encoded in their genomes. Phenotypic divergence may result from differential transcription of orthologous genes, yet less is known about the involvement of differential translation regulation in species phenotypic divergence. In order to assess translation effects on divergence, we analyzed approximately 2,800 orthologous genes in nine yeast genomes. For each gene in each species, we predicted translation efficiency, using a measure of the adaptation of its codons to the organism's tRNA pool. Mining this data set, we found hundreds of genes and gene modules with correlated patterns of translational efficiency across the species. One signal encompassed entire modules that are either needed for oxidative respiration or fermentation and are efficiently translated in aerobic or anaerobic species, respectively. In addition, the efficiency of translation of the mRNA splicing machinery strongly correlates with the number of introns in the various genomes. Altogether, we found extensive selection on synonymous codon usage that modulates translation according to gene function and organism phenotype. We conclude that, like factors such as transcription regulation, translation efficiency affects and is affected by the process of species divergence.}, address = {[1] Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel. [2] Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.}, author = {Man, Orna and Pilpel, Yitzhak }, citeulike-article-id = {1123346}, doi = {http://dx.doi.org/10.1038/ng1967}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {divergence, ortholog, phenotype, translation}, month = {February}, posted-at = {2007-03-19 12:46:58}, priority = {2}, title = {Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species.}, url = {http://dx.doi.org/10.1038/ng1967}, year = {2007} }

TY - JOUR ID - citeulike:1123346 L3 - citeulike-article-id:1123346 TI - Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species. JF - Nat Genet AD - [1] Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel. [2] Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. SN - 1061-4036 N2 - A major challenge in comparative genomics is to understand how phenotypic differences between species are encoded in their genomes. Phenotypic divergence may result from differential transcription of orthologous genes, yet less is known about the involvement of differential translation regulation in species phenotypic divergence. In order to assess translation effects on divergence, we analyzed approximately 2,800 orthologous genes in nine yeast genomes. For each gene in each species, we predicted translation efficiency, using a measure of the adaptation of its codons to the organism's tRNA pool. Mining this data set, we found hundreds of genes and gene modules with correlated patterns of translational efficiency across the species. One signal encompassed entire modules that are either needed for oxidative respiration or fermentation and are efficiently translated in aerobic or anaerobic species, respectively. In addition, the efficiency of translation of the mRNA splicing machinery strongly correlates with the number of introns in the various genomes. Altogether, we found extensive selection on synonymous codon usage that modulates translation according to gene function and organism phenotype. We conclude that, like factors such as transcription regulation, translation efficiency affects and is affected by the process of species divergence. KW - divergence KW - ortholog KW - phenotype KW - translation AU - Man, Orna AU - Pilpel, Yitzhak PY - 2007/02/04/ UR - http://dx.doi.org/10.1038/ng1967 ER -