Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2.

@article{citeulike:1187883, abstract = {The effects of a potent synthetic cannabinoid WIN 55,212-2 on nociceptive responses of wide dynamic range (WDR) neurons in the lumbar spinal cord were investigated in anesthetized rats. WDR neurons were identified by their responses to innocuous brushing and to a range of pressure stimuli from innocuous to noxious. Noxious pressure was applied to regions of the ipsilateral hind paw corresponding to the receptive field of the neuron. WIN 55,212-2 (125 micrograms/kg and 250 micrograms/kg, i.v.) produced a profound inhibition of firing evoked by the noxious pressure stimulus. By contrast, the cannabinoid did not alter the evoked activity of non-nociceptive neurons in response to non-noxious levels of stimulation. Treatment with either vehicle or the inactive enantiomer WIN 55,212-3 (250 micrograms/kg) failed to alter noxious stimulus-evoked activity of WDR neurons. These data provide direct evidence for cannabinoid-mediated inhibition of pain neurotransmission in the spinal dorsal horn. The site of action for these effects remains to be determined.}, address = {Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI, USA.}, author = {Hohmann, A. G. and Martin, W. J. and Tsou, K. and Walker, J. M. }, citeulike-article-id = {1187883}, issn = {0024-3205}, journal = {Life Sci}, keywords = {anandamide, cb-agonist, pain}, number = {23-24}, pages = {2111--2118}, posted-at = {2007-03-26 09:57:54}, priority = {4}, title = {Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7776839}, volume = {56}, year = {1995} }

TY - JOUR ID - citeulike:1187883 L3 - citeulike-article-id:1187883 TI - Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2. JF - Life Sci VL - 56 IS - 23-24 SP - 2111 EP - 2118 AD - Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI, USA. SN - 0024-3205 N2 - The effects of a potent synthetic cannabinoid WIN 55,212-2 on nociceptive responses of wide dynamic range (WDR) neurons in the lumbar spinal cord were investigated in anesthetized rats. WDR neurons were identified by their responses to innocuous brushing and to a range of pressure stimuli from innocuous to noxious. Noxious pressure was applied to regions of the ipsilateral hind paw corresponding to the receptive field of the neuron. WIN 55,212-2 (125 micrograms/kg and 250 micrograms/kg, i.v.) produced a profound inhibition of firing evoked by the noxious pressure stimulus. By contrast, the cannabinoid did not alter the evoked activity of non-nociceptive neurons in response to non-noxious levels of stimulation. Treatment with either vehicle or the inactive enantiomer WIN 55,212-3 (250 micrograms/kg) failed to alter noxious stimulus-evoked activity of WDR neurons. These data provide direct evidence for cannabinoid-mediated inhibition of pain neurotransmission in the spinal dorsal horn. The site of action for these effects remains to be determined. KW - anandamide KW - cb-agonist KW - pain AU - Hohmann, AG AU - Martin, WJ AU - Tsou, K AU - Walker, JM PY - 1995/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7776839 ER -