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The Ongoing Saga of Sirtuins and Aging

by: Matt Kaeberlein
Cell Metabolism, Vol. 8, No. 1. (2 July 2008), pp. 4-5.


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Sirtuins are known to slow aging in simple eukaryotes; however, viewing mammalian sirtuins as antiaging proteins may be overly simplistic. In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice.


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