Epigenetic control of rDNA loci in response to intracellular energy status.

@article{citeulike:2902866, abstract = {Intracellular energy balance is important for cell survival. In eukaryotic cells, the most energy-consuming process is ribosome biosynthesis, which adapts to changes in intracellular energy status. However, the mechanism that links energy status and ribosome biosynthesis is largely unknown. Here, we describe eNoSC, a protein complex that senses energy status and controls rRNA transcription. eNoSC contains Nucleomethylin, which binds histone H3 dimethylated Lys9 in the rDNA locus, in a complex with SIRT1 and SUV39H1. Both SIRT1 and SUV39H1 are required for energy-dependent transcriptional repression, suggesting that a change in the NAD(+)/NADH ratio induced by reduction of energy status could activate SIRT1, leading to deacetylation of histone H3 and dimethylation at Lys9 by SUV39H1, thus establishing silent chromatin in the rDNA locus. Furthermore, eNoSC promotes restoration of energy balance by limiting rRNA transcription, thus protecting cells from energy deprivation-dependent apoptosis. These findings provide key insight into the mechanisms of energy homeostasis in cells.}, address = {Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8572, Japan.}, author = {Murayama, A. and Ohmori, K. and Fujimura, A. and Minami, H. and Yasuzawa-Tanaka, K. and Kuroda, T. and Oie, S. and Daitoku, H. and Okuwaki, M. and Nagata, K. and Fukamizu, A. and Kimura, K. and Shimizu, T. and Yanagisawa, J. }, citeulike-article-id = {2902866}, doi = {http://dx.doi.org/10.1016/j.cell.2008.03.030}, issn = {1097-4172}, journal = {Cell}, keywords = {rdna, sir1, sirtuin}, month = {May}, number = {4}, pages = {627--639}, posted-at = {2008-07-02 21:02:28}, priority = {2}, title = {Epigenetic control of rDNA loci in response to intracellular energy status.}, url = {http://dx.doi.org/10.1016/j.cell.2008.03.030}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:2902866 L3 - citeulike-article-id:2902866 TI - Epigenetic control of rDNA loci in response to intracellular energy status. JF - Cell VL - 133 IS - 4 SP - 627 EP - 639 AD - Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8572, Japan. SN - 1097-4172 N2 - Intracellular energy balance is important for cell survival. In eukaryotic cells, the most energy-consuming process is ribosome biosynthesis, which adapts to changes in intracellular energy status. However, the mechanism that links energy status and ribosome biosynthesis is largely unknown. Here, we describe eNoSC, a protein complex that senses energy status and controls rRNA transcription. eNoSC contains Nucleomethylin, which binds histone H3 dimethylated Lys9 in the rDNA locus, in a complex with SIRT1 and SUV39H1. Both SIRT1 and SUV39H1 are required for energy-dependent transcriptional repression, suggesting that a change in the NAD(+)/NADH ratio induced by reduction of energy status could activate SIRT1, leading to deacetylation of histone H3 and dimethylation at Lys9 by SUV39H1, thus establishing silent chromatin in the rDNA locus. Furthermore, eNoSC promotes restoration of energy balance by limiting rRNA transcription, thus protecting cells from energy deprivation-dependent apoptosis. These findings provide key insight into the mechanisms of energy homeostasis in cells. KW - rdna KW - sir1 KW - sirtuin AU - Murayama, A AU - Ohmori, K AU - Fujimura, A AU - Minami, H AU - Yasuzawa-Tanaka, K AU - Kuroda, T AU - Oie, S AU - Daitoku, H AU - Okuwaki, M AU - Nagata, K AU - Fukamizu, A AU - Kimura, K AU - Shimizu, T AU - Yanagisawa, J PY - 2008/05/16/ UR - http://dx.doi.org/10.1016/j.cell.2008.03.030 ER -