[Dopamine system genes and personality traits of extraversion and novelty seeking]

@article{citeulike:971422, abstract = {Dopamine neurotransmissin is thought to play a relevant role in behavioral reinforcement system. Polymorphism of the genes involved in dopamine system has been reported for association with psychological traits related to impulsive and sensation seeking behaviors. The study was aimed at a search for association of catechol-O-metyltransferase (COMT) and dopamine receptor D4 (DRD4) gene polymorphism with personality traits in Russian population. A sample comprised 130 subjects. It was found that carriers of the Met/Met COMT genotype had higher scores of novelty seeking as compared to those with the Val/Val and Met/Met genotypes. The association was observed in women only. In the presence of the C allele of the DRD4 gene, females with the Met/Met genotype demonstrated higher scores on extraversion and hypomania. The results are consistent with the current theoretical concepts on the regulation of dopamine neurotransmission in the brain.}, author = {Golimbet, V. E. and Alfimova, M. V. and Gritsenko, I. K. and Ebshte\u{i}n, R. P. }, citeulike-article-id = {971422}, issn = {0044-4677}, journal = {Zh Vyssh Nerv Deiat Im I P Pavlova}, keywords = {dopamine, genes, system}, number = {4}, pages = {457--463}, posted-at = {2006-12-02 12:01:38}, priority = {4}, title = {[Dopamine system genes and personality traits of extraversion and novelty seeking]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17025189}, volume = {56}, year = {2006} }

TY - JOUR ID - citeulike:971422 L3 - citeulike-article-id:971422 TI - [Dopamine system genes and personality traits of extraversion and novelty seeking] JF - Zh Vyssh Nerv Deiat Im I P Pavlova VL - 56 IS - 4 SP - 457 EP - 463 SN - 0044-4677 N2 - Dopamine neurotransmissin is thought to play a relevant role in behavioral reinforcement system. Polymorphism of the genes involved in dopamine system has been reported for association with psychological traits related to impulsive and sensation seeking behaviors. The study was aimed at a search for association of catechol-O-metyltransferase (COMT) and dopamine receptor D4 (DRD4) gene polymorphism with personality traits in Russian population. A sample comprised 130 subjects. It was found that carriers of the Met/Met COMT genotype had higher scores of novelty seeking as compared to those with the Val/Val and Met/Met genotypes. The association was observed in women only. In the presence of the C allele of the DRD4 gene, females with the Met/Met genotype demonstrated higher scores on extraversion and hypomania. The results are consistent with the current theoretical concepts on the regulation of dopamine neurotransmission in the brain. KW - dopamine KW - genes KW - system AU - Golimbet, VE AU - Alfimova, MV AU - Gritsenko, IK AU - Ebshteĭn, RP PY - 2006///g UR - http://view.ncbi.nlm.nih.gov/pubmed/17025189 ER -