Targeting cancer: the challenges and successes of structure-based drug design against the human purinome

@article{citeulike:771673, abstract = {Purine-binding proteins are of critical importance to all living organisms. Approximately 13\% of the human genome is devoted to coding for purine-binding proteins. Given their importance, purine-binding proteins are attractive targets for chemotherapeutic intervention against a variety of disease states, particularly cancer. Modern computational and biophysical techniques, combined together in a structure-based drug design approach, aid immensely in the discovery of inhibitors of these targets. This review covers the process of modern structure-based drug design and gives examples of its use in discovery and development of drugs that target purine-binding proteins. The targets reviewed are human purine nucleoside phosphorylase, human epidermal growth factor receptor kinase, and human kinesin spindle protein. [Journal Article; In English; Netherlands; In-Process]}, author = {Knapp, Mark and Bellamacina, Cornelia and Murray, Jeremy M. and Bussiere, Dirksen E. }, citeulike-article-id = {771673}, journal = {Current Topics In Medicinal Chemistry}, keywords = {drug}, number = {11}, pages = {1129--1159}, posted-at = {2006-08-01 15:19:29}, priority = {2}, title = {Targeting cancer: the challenges and successes of structure-based drug design against the human purinome}, url = {http://www.sciencedirect.com/science/article/B6WVB-4KF7GDD-2DK/2/fdb6f35d4521146632fdcb528c71a881}, volume = {6}, year = {2006} }

TY - JOUR ID - citeulike:771673 L3 - citeulike-article-id:771673 TI - Targeting cancer: the challenges and successes of structure-based drug design against the human purinome JF - Current Topics In Medicinal Chemistry VL - 6 IS - 11 SP - 1129 EP - 1159 N2 - Purine-binding proteins are of critical importance to all living organisms. Approximately 13% of the human genome is devoted to coding for purine-binding proteins. Given their importance, purine-binding proteins are attractive targets for chemotherapeutic intervention against a variety of disease states, particularly cancer. Modern computational and biophysical techniques, combined together in a structure-based drug design approach, aid immensely in the discovery of inhibitors of these targets. This review covers the process of modern structure-based drug design and gives examples of its use in discovery and development of drugs that target purine-binding proteins. The targets reviewed are human purine nucleoside phosphorylase, human epidermal growth factor receptor kinase, and human kinesin spindle protein. [Journal Article; In English; Netherlands; In-Process] KW - drug AU - Knapp, Mark AU - Bellamacina, Cornelia AU - Murray, Jeremy AU - Bussiere, Dirksen PY - 2006/// UR - http://www.sciencedirect.com/science/article/B6WVB-4KF7GDD-2DK/2/fdb6f35d4521146632fdcb528c71a881 ER -