Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.

@article{citeulike:921564, abstract = {Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95\% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60\% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.}, address = {Department of Odontology, section of Oral Microbiology, Ume\r{a} University, SE-901 87 Ume\r{a}, Sweden.}, author = {Aspholm-Hurtig, M. and Dailide, G. and Lahmann, M. and Kalia, A. and Ilver, D. and Roche, N. and Vikstr\"{o}m, S. and Sj\"{o}str\"{o}m, R. and Lind\'{e}n, S. and B\"{a}ckstr\"{o}m, A. and Lundberg, C. and Arnqvist, A. and Mahdavi, J. and Nilsson, U. J. and Velapati\~{n}o, B. and Gilman, R. H. and Gerhard, M. and Alarcon, T. and L\'{o}pez-Brea, M. and Nakazawa, T. and Fox, J. G. and Correa, P. and Dominguez-Bello, M. G. and Perez-Perez, G. I. and Blaser, M. J. and Normark, S. and Carlstedt, I. and Oscarson, S. and Teneberg, S. and Berg, D. E. and Bor\'{e}n, T. }, citeulike-article-id = {921564}, doi = {10.1126/science.1098801}, issn = {1095-9203}, journal = {Science}, keywords = {baba, pylori}, month = {July}, number = {5683}, pages = {519--522}, posted-at = {2008-02-25 11:34:06}, priority = {2}, title = {Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.}, url = {http://dx.doi.org/10.1126/science.1098801}, volume = {305}, year = {2004} }

TY - JOUR ID - citeulike:921564 L3 - citeulike-article-id:921564 TI - Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. JF - Science VL - 305 IS - 5683 SP - 519 EP - 522 AD - Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden. SN - 1095-9203 N2 - Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations. KW - baba KW - pylori AU - Aspholm-Hurtig, M AU - Dailide, G AU - Lahmann, M AU - Kalia, A AU - Ilver, D AU - Roche, N AU - Vikström, S AU - Sjöström, R AU - Lindén, S AU - Bäckström, A AU - Lundberg, C AU - Arnqvist, A AU - Mahdavi, J AU - Nilsson, UJ AU - Velapatiño, B AU - Gilman, RH AU - Gerhard, M AU - Alarcon, T AU - López-Brea, M AU - Nakazawa, T AU - Fox, JG AU - Correa, P AU - Dominguez-Bello, MG AU - Perez-Perez, GI AU - Blaser, MJ AU - Normark, S AU - Carlstedt, I AU - Oscarson, S AU - Teneberg, S AU - Berg, DE AU - Borén, T PY - 2004/07/23/ UR - http://dx.doi.org/10.1126/science.1098801 ER -