A multidimensional analysis of genes mutated in breast and colorectal cancers

@article{citeulike:2019647, abstract = {A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention. 10.1101/gr.6431107}, author = {Lin, Jimmy and Gan, Christine M. and Zhang, Xiaosong and Jones, Sian and Sjoblom, Tobias and Wood, Laura D. and Parsons, Williams D. and Papadopoulos, Nickolas and Kinzler, Kenneth W. and Vogelstein, Bert and Parmigiani, Giovanni and Velculescu, Victor E. }, citeulike-article-id = {2019647}, doi = {10.1101/gr.6431107}, journal = {Genome Res.}, keywords = {breast, colon, genomics, somatic}, month = {August}, pages = {gr.6431107+}, posted-at = {2008-02-28 22:01:18}, priority = {2}, title = {A multidimensional analysis of genes mutated in breast and colorectal cancers}, url = {http://dx.doi.org/10.1101/gr.6431107}, year = {2007} }

TY - JOUR ID - citeulike:2019647 L3 - citeulike-article-id:2019647 TI - A multidimensional analysis of genes mutated in breast and colorectal cancers JF - Genome Res. SP - gr.6431107 N2 - A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention. 10.1101/gr.6431107 KW - breast KW - colon KW - genomics KW - somatic AU - Lin, Jimmy AU - Gan, Christine AU - Zhang, Xiaosong AU - Jones, Sian AU - Sjoblom, Tobias AU - Wood, Laura AU - Parsons, Williams AU - Papadopoulos, Nickolas AU - Kinzler, Kenneth AU - Vogelstein, Bert AU - Parmigiani, Giovanni AU - Velculescu, Victor PY - 2007/08/10/ UR - http://dx.doi.org/10.1101/gr.6431107 ER -