RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription

@article{citeulike:1336057, abstract = {Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the relations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides and whole-cell RNAs less than 200 nt are investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three novel potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome. 10.1126/science.1138341}, author = {Kapranov, Philipp and Cheng, Jill and Dike, Sujit and Nix, David A. and Duttagupta, Radharani and Willingham, Aarron T. and Stadler, Peter F. and Hertel, Jana and Hackermueller, Joerg and Hofacker, Ivo L. and Bell, Ian and Cheung, Evelyn and Drenkow, Jorg and Dumais, Erica and Patel, Sandeep and Helt, Gregg and Ganesh, Madhavan and Ghosh, Srinka and Piccolboni, Antonio and Sementchenko, Victor and Tammana, Hari and Gingeras, Thomas R. }, citeulike-article-id = {1336057}, doi = {10.1126/science.1138341}, journal = {Science}, keywords = {breakthrough, methods, transcriptome}, month = {May}, pages = {1138341+}, posted-at = {2008-05-06 14:39:02}, priority = {2}, title = {RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription}, url = {http://dx.doi.org/10.1126/science.1138341}, year = {2007} }

TY - JOUR ID - citeulike:1336057 TI - RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription JF - Science SP - 1138341 N2 - Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the relations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides and whole-cell RNAs less than 200 nt are investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three novel potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome. 10.1126/science.1138341 KW - breakthrough KW - methods KW - transcriptome AU - Kapranov, Philipp AU - Cheng, Jill AU - Dike, Sujit AU - Nix, David AU - Duttagupta, Radharani AU - Willingham, Aarron AU - Stadler, Peter AU - Hertel, Jana AU - Hackermueller, Joerg AU - Hofacker, Ivo AU - Bell, Ian AU - Cheung, Evelyn AU - Drenkow, Jorg AU - Dumais, Erica AU - Patel, Sandeep AU - Helt, Gregg AU - Ganesh, Madhavan AU - Ghosh, Srinka AU - Piccolboni, Antonio AU - Sementchenko, Victor AU - Tammana, Hari AU - Gingeras, Thomas PY - 2007/05/17/ UR - http://dx.doi.org/10.1126/science.1138341 ER -