Heterosynaptic LTD of Hippocampal GABAergic Synapses: A Novel Role of Endocannabinoids in Regulating Excitability

@article{citeulike:1719764, abstract = {Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.}, author = {Chevaleyre, Vivien and Castillo, Pablo E. }, citeulike-article-id = {1719764}, doi = {http://dx.doi.org/10.1016/S0896-6273(03)00235-6}, journal = {Neuron}, keywords = {cb1, endocannabinoid, exitability, gaba, ltd, ltp, neuronal, receptor, retrograde, signaling}, month = {May}, number = {3}, pages = {461--472}, posted-at = {2007-10-02 15:38:08}, priority = {2}, title = {Heterosynaptic LTD of Hippocampal GABAergic Synapses: A Novel Role of Endocannabinoids in Regulating Excitability}, url = {http://dx.doi.org/10.1016/S0896-6273(03)00235-6}, volume = {38}, year = {2003} }

TY - JOUR ID - citeulike:1719764 L3 - citeulike-article-id:1719764 TI - Heterosynaptic LTD of Hippocampal GABAergic Synapses: A Novel Role of Endocannabinoids in Regulating Excitability JF - Neuron VL - 38 IS - 3 SP - 461 EP - 472 N2 - Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory. KW - cb1 KW - endocannabinoid KW - exitability KW - gaba KW - ltd KW - ltp KW - neuronal KW - receptor KW - retrograde KW - signaling AU - Chevaleyre, Vivien AU - Castillo, Pablo PY - 2003/05/08/ UR - http://dx.doi.org/10.1016/S0896-6273(03)00235-6 ER -