RNA Quality Control in Eukaryotes

by: Meenakshi K Doma, Roy Parker

Cell, Vol. 131, No. 4. (16 November 2007), pp. 660-668.

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Abstract

Eukaryotic cells contain numerous RNA quality-control systems that are important for shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation of nonfunctional RNAs but also regulate normal mRNAs, repress viral and parasitic RNAs, and potentially contribute to the evolution of new RNAs and hence proteins. These quality-control circuits can be viewed as a series of kinetic competitions between steps in normal RNA biogenesis or function and RNA degradation pathways. These RNA quality-control circuits depend on specific adaptor proteins that target aberrant RNAs for degradation as well as the coupling of individual steps in mRNA biogenesis and function.

@article{citeulike:1925526, abstract = {Eukaryotic cells contain numerous RNA quality-control systems that are important for shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation of nonfunctional RNAs but also regulate normal mRNAs, repress viral and parasitic RNAs, and potentially contribute to the evolution of new RNAs and hence proteins. These quality-control circuits can be viewed as a series of kinetic competitions between steps in normal RNA biogenesis or function and RNA degradation pathways. These RNA quality-control circuits depend on specific adaptor proteins that target aberrant RNAs for degradation as well as the coupling of individual steps in mRNA biogenesis and function.}, author = {Doma, Meenakshi K. and Parker, Roy }, citeulike-article-id = {1925526}, doi = {http://dx.doi.org/10.1016/j.cell.2007.10.041}, journal = {Cell}, keywords = {rnai}, month = {November}, number = {4}, pages = {660--668}, posted-at = {2007-11-16 09:23:18}, priority = {4}, title = {RNA Quality Control in Eukaryotes}, url = {http://dx.doi.org/10.1016/j.cell.2007.10.041}, volume = {131}, year = {2007} }

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TY - JOUR ID - citeulike:1925526 L3 - citeulike-article-id:1925526 TI - RNA Quality Control in Eukaryotes JF - Cell VL - 131 IS - 4 SP - 660 EP - 668 N2 - Eukaryotic cells contain numerous RNA quality-control systems that are important for shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation of nonfunctional RNAs but also regulate normal mRNAs, repress viral and parasitic RNAs, and potentially contribute to the evolution of new RNAs and hence proteins. These quality-control circuits can be viewed as a series of kinetic competitions between steps in normal RNA biogenesis or function and RNA degradation pathways. These RNA quality-control circuits depend on specific adaptor proteins that target aberrant RNAs for degradation as well as the coupling of individual steps in mRNA biogenesis and function. KW - rnai AU - Doma, Meenakshi AU - Parker, Roy PY - 2007/11/16/ UR - http://dx.doi.org/10.1016/j.cell.2007.10.041 ER -

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