Lupus-associated pancreatitis.

@article{citeulike:1030318, abstract = {A number of lupus patients develop episodes of acute "idiopathic" pancreatitis, unrelated to the known causes of mechanical obstruction of the pancreatic duct or toxic-metabolic etiologies. This lupus-associated pancreatitis is rare. The estimated annual incidence was 0.4-1.1/1000 lupus patients. A literature search found detailed descriptions of this condition in 77 lupus patients. Their median age was 27, and 88\% were females. Abdominal pain was the most frequent pancreatitis-related symptom (88\%). In 97\% the diagnosis of pancreatitis was based on laboratory evidence of elevated serum amylase or lipase. Most cases were unrelated to treatment with steroids or azathioprine. Most of the patients (84\%) had active lupus at the time of pancreatitis. Mortality rate was 27\%, higher than in non-SLE associated pancreatitis. Active lupus and several biochemical abnormalities, but not treatment with steroids or azathioprine, were significantly associated with increased mortality. Treatment with steroids lowered the mortality by 67\% compared to non-treated patients.}, address = {Department of Internal Medicine, Shaare-Zedek Medical Center, P.O. Box 3235, Jerusalem 91031, Israel. gbreuer@szmc.org.il}, author = {Breuer, G. S. and Baer, A. and Dahan, D. and Nesher, G. }, citeulike-article-id = {1030318}, doi = {http://dx.doi.org/10.1016/j.autrev.2005.11.004}, issn = {1568-9972}, journal = {Autoimmun Rev}, keywords = {acute, pancreatitis}, month = {May}, number = {5}, pages = {314--318}, posted-at = {2007-01-08 18:17:15}, priority = {2}, title = {Lupus-associated pancreatitis.}, url = {http://dx.doi.org/10.1016/j.autrev.2005.11.004}, volume = {5}, year = {2006} }

TY - JOUR ID - citeulike:1030318 L3 - citeulike-article-id:1030318 TI - Lupus-associated pancreatitis. JF - Autoimmun Rev VL - 5 IS - 5 SP - 314 EP - 318 AD - Department of Internal Medicine, Shaare-Zedek Medical Center, P.O. Box 3235, Jerusalem 91031, Israel. gbreuer@szmc.org.il SN - 1568-9972 N2 - A number of lupus patients develop episodes of acute "idiopathic" pancreatitis, unrelated to the known causes of mechanical obstruction of the pancreatic duct or toxic-metabolic etiologies. This lupus-associated pancreatitis is rare. The estimated annual incidence was 0.4-1.1/1000 lupus patients. A literature search found detailed descriptions of this condition in 77 lupus patients. Their median age was 27, and 88% were females. Abdominal pain was the most frequent pancreatitis-related symptom (88%). In 97% the diagnosis of pancreatitis was based on laboratory evidence of elevated serum amylase or lipase. Most cases were unrelated to treatment with steroids or azathioprine. Most of the patients (84%) had active lupus at the time of pancreatitis. Mortality rate was 27%, higher than in non-SLE associated pancreatitis. Active lupus and several biochemical abnormalities, but not treatment with steroids or azathioprine, were significantly associated with increased mortality. Treatment with steroids lowered the mortality by 67% compared to non-treated patients. KW - acute KW - pancreatitis AU - Breuer, GS AU - Baer, A AU - Dahan, D AU - Nesher, G PY - 2006/05// UR - http://dx.doi.org/10.1016/j.autrev.2005.11.004 ER -