Gene regulatory networks and the evolution of animal body plans.

by: EH Davidson, DH Erwin

Science, Vol. 311, No. 5762. (10 February 2006), pp. 796-800.

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Abstract

Development of the animal body plan is controlled by large gene regulatory networks (GRNs), and hence evolution of body plans must depend upon change in the architecture of developmental GRNs. However, these networks are composed of diverse components that evolve at different rates and in different ways. Because of the hierarchical organization of developmental GRNs, some kinds of change affect terminal properties of the body plan such as occur in speciation, whereas others affect major aspects of body plan morphology. A notable feature of the paleontological record of animal evolution is the establishment by the Early "Cambrian of virtually all phylum-level body plans. We identify a class of GRN component, the kernels" of the network, which, because of their developmental role and their particular internal structure, are most impervious to change. Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts.

@article{citeulike:559064, abstract = {Development of the animal body plan is controlled by large gene regulatory networks (GRNs), and hence evolution of body plans must depend upon change in the architecture of developmental GRNs. However, these networks are composed of diverse components that evolve at different rates and in different ways. Because of the hierarchical organization of developmental GRNs, some kinds of change affect terminal properties of the body plan such as occur in speciation, whereas others affect major aspects of body plan morphology. A notable feature of the paleontological record of animal evolution is the establishment by the Early "Cambrian of virtually all phylum-level body plans. We identify a class of GRN component, the kernels" of the network, which, because of their developmental role and their particular internal structure, are most impervious to change. Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts.}, address = {Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu}, author = {Davidson, E. H. and Erwin, D. H. }, citeulike-article-id = {559064}, doi = {http://dx.doi.org/10.1126/science.1113832}, issn = {1095-9203}, journal = {Science}, keywords = {evolution, grn, regulatory\_network}, month = {February}, number = {5762}, pages = {796--800}, posted-at = {2007-03-22 10:45:47}, priority = {0}, title = {Gene regulatory networks and the evolution of animal body plans.}, url = {http://dx.doi.org/10.1126/science.1113832}, volume = {311}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:559064 L3 - citeulike-article-id:559064 TI - Gene regulatory networks and the evolution of animal body plans. JF - Science VL - 311 IS - 5762 SP - 796 EP - 800 AD - Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu SN - 1095-9203 N2 - Development of the animal body plan is controlled by large gene regulatory networks (GRNs), and hence evolution of body plans must depend upon change in the architecture of developmental GRNs. However, these networks are composed of diverse components that evolve at different rates and in different ways. Because of the hierarchical organization of developmental GRNs, some kinds of change affect terminal properties of the body plan such as occur in speciation, whereas others affect major aspects of body plan morphology. A notable feature of the paleontological record of animal evolution is the establishment by the Early "Cambrian of virtually all phylum-level body plans. We identify a class of GRN component, the kernels" of the network, which, because of their developmental role and their particular internal structure, are most impervious to change. Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts. KW - evolution KW - grn KW - regulatory_network AU - Davidson, EH AU - Erwin, DH PY - 2006/02/10/ UR - http://dx.doi.org/10.1126/science.1113832 ER -

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