Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key

by: Tanya Vavouri, Gayle K Mcewen, Adam Woolfe, Walter R Gilks, Greg Elgar

Trends in Genetics, Vol. 22, No. 1. (January 2006), pp. 5-10.

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Abstract

Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene.

@article{citeulike:1172474, abstract = {Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene.}, author = {Vavouri, Tanya and Mcewen, Gayle K. and Woolfe, Adam and Gilks, Walter R. and Elgar, Greg }, citeulike-article-id = {1172474}, doi = {http://dx.doi.org/10.1016/j.tig.2005.10.005}, journal = {Trends in Genetics}, keywords = {cne, enhancer, radius}, month = {January}, number = {1}, pages = {5--10}, posted-at = {2007-03-19 01:15:00}, priority = {3}, title = {Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key}, url = {http://dx.doi.org/10.1016/j.tig.2005.10.005}, volume = {22}, year = {2006} }

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TY - JOUR ID - citeulike:1172474 L3 - citeulike-article-id:1172474 TI - Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key JF - Trends in Genetics VL - 22 IS - 1 SP - 5 EP - 10 N2 - Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene. KW - cne KW - enhancer KW - radius AU - Vavouri, Tanya AU - Mcewen, Gayle AU - Woolfe, Adam AU - Gilks, Walter AU - Elgar, Greg PY - 2006/01// UR - http://dx.doi.org/10.1016/j.tig.2005.10.005 ER -

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