Programmable assembly at the molecular scale: self-assembly of DNA lattices

@inproceedings{citeulike:2286314, abstract = {DNA self-assembly is a methodology for the construction of molecular scale structures. In this method, artificially synthesized single stranded DNA self-assemble into DNA crossover molecules (tiles). These DNA tiles have sticky ends that preferentially match the sticky ends of certain other DNA tiles, facilitating the further assembly into tiling lattices. DNA self-assembly can, using only a small number of component tiles, provide arbitrarily complex assemblies. We describe various novel DNA tiles with properties that facilitate self-assembly and their visualization by imaging devices such as atomic force microscope. We discuss key theoretical and practical challenges of DNA self-assembly, as well as numerous potential applications. We briefly discuss the ongoing development of attachment chemistry from DNA lattices to various types of molecules, and consider application of DNA lattices. We also discuss bounds on the speed and error rates of the various types of self-assembly reactions, as well as methods that may minimize errors in self-assembly.}, author = {Reif, J. H. and Labean, T. H. and Seeman, N. C. }, booktitle = {Robotics and Automation, 2001. Proceedings 2001 ICRA. IEEE International Conference on}, citeulike-article-id = {2286314}, doi = {10.1109/ROBOT.2001.932675}, journal = {Robotics and Automation, 2001. Proceedings 2001 ICRA. IEEE International Conference on}, keywords = {self-assembly}, pages = {966--971 vol.1}, posted-at = {2008-01-24 23:33:13}, priority = {2}, title = {Programmable assembly at the molecular scale: self-assembly of DNA lattices}, url = {http://dx.doi.org/10.1109/ROBOT.2001.932675}, volume = {1}, year = {2001} }

TY - CONF ID - citeulike:2286314 L3 - citeulike-article-id:2286314 TI - Programmable assembly at the molecular scale: self-assembly of DNA lattices T2 - Robotics and Automation, 2001. Proceedings 2001 ICRA. IEEE International Conference on JF - Robotics and Automation, 2001. Proceedings 2001 ICRA. IEEE International Conference on VL - 1 SP - 966 EP - 971 vol.1 N2 - DNA self-assembly is a methodology for the construction of molecular scale structures. In this method, artificially synthesized single stranded DNA self-assemble into DNA crossover molecules (tiles). These DNA tiles have sticky ends that preferentially match the sticky ends of certain other DNA tiles, facilitating the further assembly into tiling lattices. DNA self-assembly can, using only a small number of component tiles, provide arbitrarily complex assemblies. We describe various novel DNA tiles with properties that facilitate self-assembly and their visualization by imaging devices such as atomic force microscope. We discuss key theoretical and practical challenges of DNA self-assembly, as well as numerous potential applications. We briefly discuss the ongoing development of attachment chemistry from DNA lattices to various types of molecules, and consider application of DNA lattices. We also discuss bounds on the speed and error rates of the various types of self-assembly reactions, as well as methods that may minimize errors in self-assembly. KW - self-assembly AU - Reif, JH AU - Labean, TH AU - Seeman, NC PY - 2001/// UR - http://dx.doi.org/10.1109/ROBOT.2001.932675 ER -