Memory strength and repetition suppression: multimodal imaging of medial temporal cortical contributions to recognition.

@article{citeulike:319863, abstract = {Declarative memory permits an organism to recognize stimuli that have been previously encountered, discriminating them from those that are novel. One basis for recognition is item memory strength, which may support the perception of stimulus familiarity. Though the medial temporal lobes are known to be critical for declarative memory, at present the neural mechanisms supporting perceived differences in memory strength remain poorly specified. Here, functional MRI (fMRI) and anatomically constrained magnetoencephalography (MEG) indexed correlates of graded memory strength in the human brain, focusing on medial temporal cortex. fMRI revealed a decrease in medial temporal cortical activation that tracked parametric levels of perceived memory strength. Anatomically constrained MEG current estimates revealed that strength-dependent signal reductions onset within 150-300 ms. Memory strength appears to be rapidly signaled by medial temporal cortex through repetition suppression (activation reductions), providing a basis for the subjective perception of stimulus familiarity or novelty.}, address = {Department of Psychology andNeurosciences Program, Stanford University, Stanford, California 94305.}, author = {Gonsalves, B. D. and Kahn, I. and Curran, T. and Norman, K. A. and Wagner, A. D. }, citeulike-article-id = {319863}, doi = {http://dx.doi.org/10.1016/j.neuron.2005.07.013}, issn = {0896-6273}, journal = {Neuron}, keywords = {recognition, repetitions-priming}, month = {September}, number = {5}, pages = {751--761}, posted-at = {2005-09-14 15:19:08}, priority = {2}, title = {Memory strength and repetition suppression: multimodal imaging of medial temporal cortical contributions to recognition.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.07.013}, volume = {47}, year = {2005} }

TY - JOUR ID - citeulike:319863 L3 - citeulike-article-id:319863 TI - Memory strength and repetition suppression: multimodal imaging of medial temporal cortical contributions to recognition. JF - Neuron VL - 47 IS - 5 SP - 751 EP - 761 AD - Department of Psychology andNeurosciences Program, Stanford University, Stanford, California 94305. SN - 0896-6273 N2 - Declarative memory permits an organism to recognize stimuli that have been previously encountered, discriminating them from those that are novel. One basis for recognition is item memory strength, which may support the perception of stimulus familiarity. Though the medial temporal lobes are known to be critical for declarative memory, at present the neural mechanisms supporting perceived differences in memory strength remain poorly specified. Here, functional MRI (fMRI) and anatomically constrained magnetoencephalography (MEG) indexed correlates of graded memory strength in the human brain, focusing on medial temporal cortex. fMRI revealed a decrease in medial temporal cortical activation that tracked parametric levels of perceived memory strength. Anatomically constrained MEG current estimates revealed that strength-dependent signal reductions onset within 150-300 ms. Memory strength appears to be rapidly signaled by medial temporal cortex through repetition suppression (activation reductions), providing a basis for the subjective perception of stimulus familiarity or novelty. KW - recognition KW - repetitions-priming AU - Gonsalves, BD AU - Kahn, I AU - Curran, T AU - Norman, KA AU - Wagner, AD PY - 2005/09/01/ UR - http://dx.doi.org/10.1016/j.neuron.2005.07.013 ER -