Prefrontal cortex and basal ganglia control access to working memory.

@article{citeulike:2138255, abstract = {Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity.}, address = {Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, N8:00, 17176 Stockholm, Sweden.}, author = {McNab, Fiona and Klingberg, Torkel }, citeulike-article-id = {2138255}, doi = {http://dx.doi.org/10.1038/nn2024}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {arash, brian, fmri, jessica, jie, joo-seok, kristina, shiva, working\_memory}, month = {December}, posted-at = {2007-12-17 21:12:01}, priority = {2}, title = {Prefrontal cortex and basal ganglia control access to working memory.}, url = {http://dx.doi.org/10.1038/nn2024}, year = {2007} }

TY - JOUR ID - citeulike:2138255 L3 - citeulike-article-id:2138255 TI - Prefrontal cortex and basal ganglia control access to working memory. JF - Nat Neurosci AD - Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, N8:00, 17176 Stockholm, Sweden. SN - 1097-6256 N2 - Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity. KW - arash KW - brian KW - fmri KW - jessica KW - jie KW - joo-seok KW - kristina KW - shiva KW - working_memory AU - McNab, Fiona AU - Klingberg, Torkel PY - 2007/12/09/ UR - http://dx.doi.org/10.1038/nn2024 ER -