VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism.

@article{citeulike:2905754, abstract = {Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.}, address = {Institute of Microbiology and Genetics, Georg August University, D-37077 G\"{o}ttingen, Germany.}, author = {Bayram, O. and Krappmann, S. and Ni, M. and Bok, J. W. and Helmstaedt, K. and Valerius, O. and Braus-Stromeyer, S. and Kwon, N. J. and Keller, N. P. and Yu, J. H. and Braus, G. H. }, citeulike-article-id = {2905754}, doi = {http://dx.doi.org/10.1126/science.1155888}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {aspergillus, development, gene\_expression, light\_response, secondary\_metabolite}, month = {June}, number = {5882}, pages = {1504--1506}, posted-at = {2008-07-07 03:38:45}, priority = {2}, title = {VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism.}, url = {http://dx.doi.org/10.1126/science.1155888}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2905754 L3 - citeulike-article-id:2905754 TI - VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. JF - Science (New York, N.Y.) VL - 320 IS - 5882 SP - 1504 EP - 1506 AD - Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany. SN - 1095-9203 N2 - Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites. KW - aspergillus KW - development KW - gene_expression KW - light_response KW - secondary_metabolite AU - Bayram, O AU - Krappmann, S AU - Ni, M AU - Bok, JW AU - Helmstaedt, K AU - Valerius, O AU - Braus-Stromeyer, S AU - Kwon, NJ AU - Keller, NP AU - Yu, JH AU - Braus, GH PY - 2008/06/13/ UR - http://dx.doi.org/10.1126/science.1155888 ER -