MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control

by: Yi Zhao, Shunmin He, Changning Liu, Songwei Ru, Haitao Zhao, Zhen Yang, Pengcheng Yang, Xiongyin Yuan, Shiwei Sun, Dongbo Bu, Jiefu Huang, Geir Skogerbø, Runsheng Chen

Trends in Genetics, Vol. In Press, Corrected Proof

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Abstract

Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (mlRNAs). To investigate whether mlRNAs are subject to miRNA control, we compared the expression of mlRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mlRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control.

@article{citeulike:2861200, abstract = {Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (mlRNAs). To investigate whether mlRNAs are subject to miRNA control, we compared the expression of mlRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mlRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control.}, author = {Zhao, Yi and He, Shunmin and Liu, Changning and Ru, Songwei and Zhao, Haitao and Yang, Zhen and Yang, Pengcheng and Yuan, Xiongyin and Sun, Shiwei and Bu, Dongbo and Huang, Jiefu and Skogerbø, Geir and Chen, Runsheng }, citeulike-article-id = {2861200}, doi = {http://dx.doi.org/10.1016/j.tig.2008.04.004}, journal = {Trends in Genetics}, keywords = {gene\_expression, metazoan, mirna, noncoding\_rna, regulation, regulatory\_evolution}, posted-at = {2008-06-22 20:12:10}, priority = {2}, title = {MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control}, url = {http://dx.doi.org/10.1016/j.tig.2008.04.004}, volume = {In Press, Corrected Proof} }

RIS record

TY - JOUR ID - citeulike:2861200 L3 - citeulike-article-id:2861200 TI - MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control JF - Trends in Genetics VL - In Press, Corrected Proof N2 - Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (mlRNAs). To investigate whether mlRNAs are subject to miRNA control, we compared the expression of mlRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mlRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control. KW - gene_expression KW - metazoan KW - mirna KW - noncoding_rna KW - regulation KW - regulatory_evolution AU - Zhao, Yi AU - He, Shunmin AU - Liu, Changning AU - Ru, Songwei AU - Zhao, Haitao AU - Yang, Zhen AU - Yang, Pengcheng AU - Yuan, Xiongyin AU - Sun, Shiwei AU - Bu, Dongbo AU - Huang, Jiefu AU - Skogerbø, Geir AU - Chen, Runsheng UR - http://dx.doi.org/10.1016/j.tig.2008.04.004 ER -

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