Resolution of renal adenocarcinoma-induced secondary inappropriate polycythaemia after nephrectomy in two cats.

@article{citeulike:2453952, abstract = {Two cases of secondary, inappropriate polycythaemia caused by renal adenocarcinoma in domestic shorthair cats, are described. The cats were 9 and 12 years old and both were presented because of generalised seizures presumably due to hyperviscosity. Both cats had a markedly increased haematocrit (0.770 and 0.632l/l) and thrombocytosis (744x10(9)/l and 926x10(9)/l). An abdominal ultrasound revealed a mass in the cranial pole of one kidney in both cats. Serum erythropoietin (EPO) concentration was within the reference interval (RI) in both cats but was inappropriately high considering the markedly increased haematocrit. The cats were initially stabilised and managed by multiple phlebotomies and intravenous fluid therapy and underwent nephrectomy of the affected kidney later on. Both the polycythaemia and thrombocytosis resolved following surgery. Postoperative serum EPO concentration, measured in one cat, decreased markedly. Histopathology of the affected kidneys confirmed a diagnosis of renal adenocarcinoma. Both cats were stable for an 8-month follow-up period; however, one cat had developed a stable chronic kidney disease (CKD), while the other was represented 8 months postoperatively due to dyspnoea, and had radiographic evidence of lung metastasis, presumably because of the spread of the original renal tumour and was euthanased. Initial stabilisation of polycythaemic cats should include multiple phlebotomies. Nephrectomy should be considered in cats with secondary, inappropriate, renal adenocarcinoma-related polycythaemia when only one kidney is affected by the tumour, and provided that the other kidney's function is satisfactory. Nephrectomy should be expected to resolve the polycythaemia and lead to normalisation of serum EPO concentration.}, address = {Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel.}, author = {Klainbart, Sigal and Segev, Gilad and Loeb, Emmanuel and Melamed, Dana and Aroch, Itamar }, citeulike-article-id = {2453952}, doi = {http://dx.doi.org/10.1016/j.jfms.2007.11.006}, issn = {1098-612X}, journal = {J Feline Med Surg}, keywords = {adenocarcinoma, cat, nephrectomy, polycythaemia, renal, resolution, secondary, ultrasound}, month = {February}, posted-at = {2008-03-01 23:00:31}, priority = {2}, title = {Resolution of renal adenocarcinoma-induced secondary inappropriate polycythaemia after nephrectomy in two cats.}, url = {http://dx.doi.org/10.1016/j.jfms.2007.11.006}, year = {2008} }

TY - JOUR ID - citeulike:2453952 L3 - citeulike-article-id:2453952 TI - Resolution of renal adenocarcinoma-induced secondary inappropriate polycythaemia after nephrectomy in two cats. JF - J Feline Med Surg AD - Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel. SN - 1098-612X N2 - Two cases of secondary, inappropriate polycythaemia caused by renal adenocarcinoma in domestic shorthair cats, are described. The cats were 9 and 12 years old and both were presented because of generalised seizures presumably due to hyperviscosity. Both cats had a markedly increased haematocrit (0.770 and 0.632l/l) and thrombocytosis (744x10(9)/l and 926x10(9)/l). An abdominal ultrasound revealed a mass in the cranial pole of one kidney in both cats. Serum erythropoietin (EPO) concentration was within the reference interval (RI) in both cats but was inappropriately high considering the markedly increased haematocrit. The cats were initially stabilised and managed by multiple phlebotomies and intravenous fluid therapy and underwent nephrectomy of the affected kidney later on. Both the polycythaemia and thrombocytosis resolved following surgery. Postoperative serum EPO concentration, measured in one cat, decreased markedly. Histopathology of the affected kidneys confirmed a diagnosis of renal adenocarcinoma. Both cats were stable for an 8-month follow-up period; however, one cat had developed a stable chronic kidney disease (CKD), while the other was represented 8 months postoperatively due to dyspnoea, and had radiographic evidence of lung metastasis, presumably because of the spread of the original renal tumour and was euthanased. Initial stabilisation of polycythaemic cats should include multiple phlebotomies. Nephrectomy should be considered in cats with secondary, inappropriate, renal adenocarcinoma-related polycythaemia when only one kidney is affected by the tumour, and provided that the other kidney's function is satisfactory. Nephrectomy should be expected to resolve the polycythaemia and lead to normalisation of serum EPO concentration. KW - adenocarcinoma KW - cat KW - nephrectomy KW - polycythaemia KW - renal KW - resolution KW - secondary KW - ultrasound AU - Klainbart, Sigal AU - Segev, Gilad AU - Loeb, Emmanuel AU - Melamed, Dana AU - Aroch, Itamar PY - 2008/02/07/ UR - http://dx.doi.org/10.1016/j.jfms.2007.11.006 ER -