Hyperactivity-inattention symptoms in childhood and substance use in adolescence: The youth gazel cohortDrug and Alcohol Dependence, Vol. 94, No. 1-3. (1 April 2008), pp. 30-37.
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AbstractBackground This study addresses in both genders the relationship between childhood Hyperactivity-inattention symptoms and subsequent adolescent substance use, while controlling for psychiatric comorbidity, temperament and environmental risk factors.Methods 916 subjects (421 males, 495 females) aged 7-18 were recruited from the general population and surveyed in 1991 and 1999. Child psychopathology and substance use patterns were evaluated through parent and adolescent self-reports. Multivariate modeling was performed to assess the effects of childhood Hyperactivity-inattention symptoms and other risk factors on adolescent substance use.Results In males, Hyperactivity-inattention symptoms alone accounted for the risk of subsequent regular cannabis smoking (OR = 3.14, p = 0.03) and subsequent lifetime use of other drugs including stimulants, opiates, inhalants and sedatives (OR = 2.72, p = 0.02). In females, Hyperactivity-inattention symptoms did not independently increase the liability to later substance use. In males, the temperament trait activity was a significant predictor of subsequent regular cannabis smoking (OR = 2.32, p = 0.04).Conclusions This survey points to a possible specific link between Hyperactivity-inattention symptoms and subsequent cannabis use and experimentation of harder drugs in males.
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