Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling

@article{citeulike:2658525, abstract = {Execution of motor behaviors relies on circuitries effectively integrating immediate sensory feedback to efferent pathways controlling muscle activity. It remains unclear how, during neuromuscular circuit assembly, sensory and motor projections become incorporated into tightly coordinated, yet functionally separate pathways. We report that, within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections. These heterotypic axon-axon interactions require motor axonal EphA3/EphA4 receptor tyrosine kinases activated by cognate sensory axonal ephrin-A ligands. Genetic elimination of trans-axonal ephrin-A [-\>] EphA signaling in mice triggers drastic motor-sensory miswiring, culminating in functional efferents within proximal afferent pathways. Effective assembly of a key circuit underlying motor behaviors thus critically depends on trans-axonal signaling interactions resolving motor and sensory projections into discrete pathways. 10.1126/science.1153758}, author = {Gallarda, Benjamin W. and Bonanomi, Dario and Muller, Daniel and Brown, Arthur and Alaynick, William A. and Andrews, Shane E. and Lemke, Greg and Pfaff, Samuel L. and Marquardt, Till }, citeulike-article-id = {2658525}, doi = {10.1126/science.1153758}, journal = {Science}, keywords = {brian, general, motor-control, neural-organization, nichola}, month = {April}, number = {5873}, pages = {233--236}, posted-at = {2008-04-11 19:07:35}, priority = {2}, title = {Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling}, url = {http://dx.doi.org/10.1126/science.1153758}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2658525 L3 - citeulike-article-id:2658525 TI - Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling JF - Science VL - 320 IS - 5873 SP - 233 EP - 236 N2 - Execution of motor behaviors relies on circuitries effectively integrating immediate sensory feedback to efferent pathways controlling muscle activity. It remains unclear how, during neuromuscular circuit assembly, sensory and motor projections become incorporated into tightly coordinated, yet functionally separate pathways. We report that, within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections. These heterotypic axon-axon interactions require motor axonal EphA3/EphA4 receptor tyrosine kinases activated by cognate sensory axonal ephrin-A ligands. Genetic elimination of trans-axonal ephrin-A [->] EphA signaling in mice triggers drastic motor-sensory miswiring, culminating in functional efferents within proximal afferent pathways. Effective assembly of a key circuit underlying motor behaviors thus critically depends on trans-axonal signaling interactions resolving motor and sensory projections into discrete pathways. 10.1126/science.1153758 KW - brian KW - general KW - motor-control KW - neural-organization KW - nichola AU - Gallarda, Benjamin AU - Bonanomi, Dario AU - Muller, Daniel AU - Brown, Arthur AU - Alaynick, William AU - Andrews, Shane AU - Lemke, Greg AU - Pfaff, Samuel AU - Marquardt, Till PY - 2008/04/11/ UR - http://dx.doi.org/10.1126/science.1153758 ER -