The role of prefrontal cortex in resolving distractor interference.

@article{citeulike:1434814, abstract = {We investigate the hypothesis that those subregions of the prefrontal cortex (PFC) found to support proactive interference resolution may also support delay-spanning distractor interference resolution. Ten subjects performed delayed-recognition tasks requiring working memory for faces or shoes during functional MRI scanning. During the 15-sec delay interval, task-irrelevant distractors were presented. These distractors were either all faces or all shoes and were thus either congruent or incongruent with the domain of items in the working memory task. Delayed-recognition performance was slower and less accurate during congruent than during incongruent trials. Our fMRI analyses revealed significant delay interval activity for face and shoe working memory tasks within both dorsal and ventral PFC. However, only ventral PFC activity was modulated by distractor category, with greater activity for congruent than for incongruent trials. Importantly, this congruency effect was only present for correct trials. In addition to PFC, activity within the fusiform face area was investigated. During face distraction, activity was greater for face relative to shoe working memory. As in ventrolateral PFC, this congruency effect was only present for correct trials. These results suggest that the ventrolateral PFC and fusiform face area may work together to support delay-spanning interference resolution.}, address = {Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. apjha@psych.upenn.edu}, author = {Jha, A. P. and Fabian, S. A. and Aguirre, G. K. }, citeulike-article-id = {1434814}, issn = {1530-7026}, journal = {Cogn Affect Behav Neurosci}, keywords = {distractor, fmri, interference, pfc}, month = {December}, number = {4}, pages = {517--527}, posted-at = {2007-07-05 05:06:54}, priority = {3}, title = {The role of prefrontal cortex in resolving distractor interference.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15849894}, volume = {4}, year = {2004} }

TY - JOUR ID - citeulike:1434814 L3 - citeulike-article-id:1434814 TI - The role of prefrontal cortex in resolving distractor interference. JF - Cogn Affect Behav Neurosci VL - 4 IS - 4 SP - 517 EP - 527 AD - Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. apjha@psych.upenn.edu SN - 1530-7026 N2 - We investigate the hypothesis that those subregions of the prefrontal cortex (PFC) found to support proactive interference resolution may also support delay-spanning distractor interference resolution. Ten subjects performed delayed-recognition tasks requiring working memory for faces or shoes during functional MRI scanning. During the 15-sec delay interval, task-irrelevant distractors were presented. These distractors were either all faces or all shoes and were thus either congruent or incongruent with the domain of items in the working memory task. Delayed-recognition performance was slower and less accurate during congruent than during incongruent trials. Our fMRI analyses revealed significant delay interval activity for face and shoe working memory tasks within both dorsal and ventral PFC. However, only ventral PFC activity was modulated by distractor category, with greater activity for congruent than for incongruent trials. Importantly, this congruency effect was only present for correct trials. In addition to PFC, activity within the fusiform face area was investigated. During face distraction, activity was greater for face relative to shoe working memory. As in ventrolateral PFC, this congruency effect was only present for correct trials. These results suggest that the ventrolateral PFC and fusiform face area may work together to support delay-spanning interference resolution. KW - distractor KW - fmri KW - interference KW - pfc AU - Jha, AP AU - Fabian, SA AU - Aguirre, GK PY - 2004/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/15849894 ER -