Learning-specific changes in long-term depression in adult perirhinal cortex.

@article{citeulike:3042962, abstract = {Learning is widely believed to involve synaptic plasticity, using mechanisms such as those used in long-term potentiation (LTP). We assess whether the mechanisms used in alternative forms of plasticity, long-term depression (LTD) and depotentiation, play a role in learning. We have exploited the involvement of the perirhinal cortex in two different forms of learning to compare simultaneously, within the same brain region, their effects on LTD and depotentiation. Multiple-exposure learning but not single-exposure learning in vivo prevented, in a muscarinic receptor-dependent manner, subsequent induction of LTD and depotentiation, but not LTP, in perirhinal cortex in vitro. The contrast in the effects of the two types of learning under these particular experimental conditions indicate that the in vitro change is unlikely to be attributable to synapse-specific plastic changes registering the precise details of the individual learned associations. Instead, it is concluded that the lack of LTD and depotentiation arises from, and establishes the importance of, a learning-related generalized change in plasticity gain. The existence of this additional mechanism has important implications for interpretations of how plasticity relates to learning.}, address = {Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, United Kingdom.}, author = {Massey, P. V. and Phythian, D. and Narduzzo, K. and Warburton, E. C. and Brown, M. W. and Bashir, Z. I. }, citeulike-article-id = {3042962}, doi = {http://dx.doi.org/10.1523/JNEUROSCI.1935-08.2008}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {learning, plasticity}, month = {July}, number = {30}, pages = {7548--7554}, posted-at = {2008-07-25 17:11:44}, priority = {2}, title = {Learning-specific changes in long-term depression in adult perirhinal cortex.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.1935-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:3042962 L3 - citeulike-article-id:3042962 TI - Learning-specific changes in long-term depression in adult perirhinal cortex. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience VL - 28 IS - 30 SP - 7548 EP - 7554 AD - Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, United Kingdom. SN - 1529-2401 N2 - Learning is widely believed to involve synaptic plasticity, using mechanisms such as those used in long-term potentiation (LTP). We assess whether the mechanisms used in alternative forms of plasticity, long-term depression (LTD) and depotentiation, play a role in learning. We have exploited the involvement of the perirhinal cortex in two different forms of learning to compare simultaneously, within the same brain region, their effects on LTD and depotentiation. Multiple-exposure learning but not single-exposure learning in vivo prevented, in a muscarinic receptor-dependent manner, subsequent induction of LTD and depotentiation, but not LTP, in perirhinal cortex in vitro. The contrast in the effects of the two types of learning under these particular experimental conditions indicate that the in vitro change is unlikely to be attributable to synapse-specific plastic changes registering the precise details of the individual learned associations. Instead, it is concluded that the lack of LTD and depotentiation arises from, and establishes the importance of, a learning-related generalized change in plasticity gain. The existence of this additional mechanism has important implications for interpretations of how plasticity relates to learning. KW - learning KW - plasticity AU - Massey, PV AU - Phythian, D AU - Narduzzo, K AU - Warburton, EC AU - Brown, MW AU - Bashir, ZI PY - 2008/07/23/ UR - http://dx.doi.org/10.1523/JNEUROSCI.1935-08.2008 ER -