Defining memories by their distinct molecular traces

@article{citeulike:2718521, abstract = {It is often stated that short-term memory is consolidated in a protein-synthesis-dependent manner into long-term memory. Alternatively, memories might consist of distinct molecular traces that last for different periods of time. These traces can be graded by their [`]volatility'; traces encoded by activation of protein kinases are more volatile than traces encoded by morphological changes at preexisting synapses. The least volatile ([`]static') traces are due to the generation and stabilization of new synapses. Importantly, whereas at the cellular level these traces are generated independently of each other, they might be linked at the network level where volatile memory traces are required to set up a cellular network that is in turn required to induce the static memory trace.}, author = {Sossin, Wayne S. }, citeulike-article-id = {2718521}, doi = {10.1016/j.tins.2008.01.001}, journal = {Trends in Neurosciences}, keywords = {consolidation, kinases, memory}, month = {April}, number = {4}, pages = {170--175}, posted-at = {2008-05-19 19:00:02}, priority = {2}, title = {Defining memories by their distinct molecular traces}, url = {http://dx.doi.org/10.1016/j.tins.2008.01.001}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2718521 L3 - citeulike-article-id:2718521 TI - Defining memories by their distinct molecular traces JF - Trends in Neurosciences VL - 31 IS - 4 SP - 170 EP - 175 N2 - It is often stated that short-term memory is consolidated in a protein-synthesis-dependent manner into long-term memory. Alternatively, memories might consist of distinct molecular traces that last for different periods of time. These traces can be graded by their [`]volatility'; traces encoded by activation of protein kinases are more volatile than traces encoded by morphological changes at preexisting synapses. The least volatile ([`]static') traces are due to the generation and stabilization of new synapses. Importantly, whereas at the cellular level these traces are generated independently of each other, they might be linked at the network level where volatile memory traces are required to set up a cellular network that is in turn required to induce the static memory trace. KW - consolidation KW - kinases KW - memory AU - Sossin, Wayne PY - 2008/04// UR - http://dx.doi.org/10.1016/j.tins.2008.01.001 ER -