Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury

@article{citeulike:2635768, abstract = {Brain hypoxia-ischemia is a relatively common and serious problem in neonates and in adults. Its consequences include long-term histological and behavioral changes and reduction in seizure threshold. Gap junction intercellular communication is pivotal in the spread of hypoxia-ischemia related injury and in mediating its long-term effects. This review provides a comprehensive and critical review of hypoxia-ischemia and hypoxia in the brain and the potential role of gap junctions in the spread of the neuronal injury induced by these insults. It also presents the effects of hypoxia-ischemia and of hypoxia on the state of gap junctions in vitro and in vivo. Understanding the mechanisms involved in gap junction-mediated neuronal injury due to hypoxia will lead to the development of novel therapeutic strategies.}, author = {Talhouk, Rabih S. and Zeinieh, Michele P. and Mikati, Mohamad A. and El-Sabban, Marwan E. }, citeulike-article-id = {2635768}, doi = {10.1016/j.pneurobio.2007.10.001}, journal = {Progress in Neurobiology}, month = {January}, number = {1}, pages = {57--76}, posted-at = {2008-04-07 01:35:47}, priority = {2}, title = {Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury}, url = {http://dx.doi.org/10.1016/j.pneurobio.2007.10.001}, volume = {84}, year = {2008} }

TY - JOUR ID - citeulike:2635768 L3 - citeulike-article-id:2635768 TI - Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury JF - Progress in Neurobiology VL - 84 IS - 1 SP - 57 EP - 76 N2 - Brain hypoxia-ischemia is a relatively common and serious problem in neonates and in adults. Its consequences include long-term histological and behavioral changes and reduction in seizure threshold. Gap junction intercellular communication is pivotal in the spread of hypoxia-ischemia related injury and in mediating its long-term effects. This review provides a comprehensive and critical review of hypoxia-ischemia and hypoxia in the brain and the potential role of gap junctions in the spread of the neuronal injury induced by these insults. It also presents the effects of hypoxia-ischemia and of hypoxia on the state of gap junctions in vitro and in vivo. Understanding the mechanisms involved in gap junction-mediated neuronal injury due to hypoxia will lead to the development of novel therapeutic strategies. AU - Talhouk, Rabih AU - Zeinieh, Michele AU - Mikati, Mohamad AU - El-Sabban, Marwan PY - 2008/01// UR - http://dx.doi.org/10.1016/j.pneurobio.2007.10.001 ER -