Review. Context-induced relapse to drug seeking: a review.

@article{citeulike:3032854, abstract = {In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton \& Bolles on context-induced 'renewal' of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-administer drug in one context. Next, drug-reinforced lever responding is extinguished in a different (non-drug) context. Subsequently, context-induced reinstatement of drug seeking is assessed by re-exposing rats to the drug-associated context. Using variations of this procedure, we and others reported reliable context-induced reinstatement in rats with a history of heroin, cocaine, heroin-cocaine combination, alcohol and nicotine self-administration. Here, we first discuss potential psychological mechanisms of context-induced reinstatement, including excitatory and inhibitory Pavlovian conditioning, and occasion setting. We then summarize results from pharmacological and neuroanatomical studies on the role of several neurotransmitter systems (dopamine, glutamate, serotonin and opioids) and brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, dorsal hippocampus and lateral hypothalamus) in context-induced reinstatement. We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking.}, address = {Behavioural and Clinical Neuroscience Group, Department of Psychology, School of Life Sciences, The University of Sussex, Brighton BN1 9RH, UK.}, author = {Crombag, Hans S S. and Bossert, Jennifer M M. and Koya, Eisuke and Shaham, Yavin }, citeulike-article-id = {3032854}, doi = {10.1098/rstb.2008.0090}, issn = {0962-8436}, journal = {Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, month = {July}, posted-at = {2008-07-22 15:14:09}, priority = {2}, title = {Review. Context-induced relapse to drug seeking: a review.}, url = {http://dx.doi.org/10.1098/rstb.2008.0090}, year = {2008} }

TY - JOUR ID - citeulike:3032854 L3 - citeulike-article-id:3032854 TI - Review. Context-induced relapse to drug seeking: a review. JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences AD - Behavioural and Clinical Neuroscience Group, Department of Psychology, School of Life Sciences, The University of Sussex, Brighton BN1 9RH, UK. SN - 0962-8436 N2 - In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton & Bolles on context-induced 'renewal' of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-administer drug in one context. Next, drug-reinforced lever responding is extinguished in a different (non-drug) context. Subsequently, context-induced reinstatement of drug seeking is assessed by re-exposing rats to the drug-associated context. Using variations of this procedure, we and others reported reliable context-induced reinstatement in rats with a history of heroin, cocaine, heroin-cocaine combination, alcohol and nicotine self-administration. Here, we first discuss potential psychological mechanisms of context-induced reinstatement, including excitatory and inhibitory Pavlovian conditioning, and occasion setting. We then summarize results from pharmacological and neuroanatomical studies on the role of several neurotransmitter systems (dopamine, glutamate, serotonin and opioids) and brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, dorsal hippocampus and lateral hypothalamus) in context-induced reinstatement. We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking. AU - Crombag, Hans S AU - Bossert, Jennifer M AU - Koya, Eisuke AU - Shaham, Yavin PY - 2008/07/18/ UR - http://dx.doi.org/10.1098/rstb.2008.0090 ER -