The evolution of resistance genes in multi-protein plant resistance systems

@article{citeulike:1813305, abstract = {The genomic perspective aids in integrating the analysis of single resistance (R-) genes into a higher order model of complex plant resistance systems. The majority of R-genes encode a class of proteins with nucleotide binding (NB) and leucine-rich repeat (LRR) domains. Several R-proteins act in multi-protein R-complexes that mediate interaction with pathogen effectors to induce resistance signaling. The complexity of these systems seems to have resulted from multiple rounds of plant-pathogen co-evolution. R-gene evolution is thought to be facilitated by the formation of R-gene clusters, which permit sequence exchanges via recombinatorial mispairing and generate high haplotypic diversity. This pattern of evolution may also generate diversity at other loci that contribute to the R-complex. The rate of recombination at R-clusters is not necessarily homogeneous or consistent over evolutionary time: recent evidence suggests that recombination at R-clusters is increased following pathogen infection, suggesting a mechanism that induces temporary genome instability in response to extreme stress. DNA methylation and chromatin modifications may allow this instability to be conditionally regulated and targeted to specific genome regions. Knowledge of natural R-gene evolution may contribute to strategies for artificial evolution of novel resistance specificities.}, author = {Friedman, Aaron R. and Baker, Barbara J. }, citeulike-article-id = {1813305}, doi = {http://dx.doi.org/10.1016/j.gde.2007.08.014}, journal = {Current Opinion in Genetics \& Development}, keywords = {r, review}, posted-at = {2007-10-24 00:55:09}, priority = {2}, title = {The evolution of resistance genes in multi-protein plant resistance systems}, url = {http://dx.doi.org/10.1016/j.gde.2007.08.014}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:1813305 L3 - citeulike-article-id:1813305 N2 - The genomic perspective aids in integrating the analysis of single resistance (R-) genes into a higher order model of complex plant resistance systems. The majority of R-genes encode a class of proteins with nucleotide binding (NB) and leucine-rich repeat (LRR) domains. Several R-proteins act in multi-protein R-complexes that mediate interaction with pathogen effectors to induce resistance signaling. The complexity of these systems seems to have resulted from multiple rounds of plant-pathogen co-evolution. R-gene evolution is thought to be facilitated by the formation of R-gene clusters, which permit sequence exchanges via recombinatorial mispairing and generate high haplotypic diversity. This pattern of evolution may also generate diversity at other loci that contribute to the R-complex. The rate of recombination at R-clusters is not necessarily homogeneous or consistent over evolutionary time: recent evidence suggests that recombination at R-clusters is increased following pathogen infection, suggesting a mechanism that induces temporary genome instability in response to extreme stress. DNA methylation and chromatin modifications may allow this instability to be conditionally regulated and targeted to specific genome regions. Knowledge of natural R-gene evolution may contribute to strategies for artificial evolution of novel resistance specificities. JF - Current Opinion in Genetics & Development TI - The evolution of resistance genes in multi-protein plant resistance systems VL - In Press, Corrected Proof KW - r KW - review AU - Friedman, Aaron AU - Baker, Barbara UR - http://dx.doi.org/10.1016/j.gde.2007.08.014 ER -