Chromosomal Aberration Frequency in Lymphocytes Predicts the Risk of Cancer: Results from a Pooled Cohort Study of 22,358 Subjects in 11 Countries.

@article{citeulike:2757866, abstract = {Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies which associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22,358 cancer free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium (RR = 1.31; 95\% confidence interval (CI) 1.07-1.60) and in the high (RR = 1.41; 95\% CI 1.16-1.72) tertiles, when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95\% CI= 1.34-3.68). The strongest association was found for stomach cancer (RR(medium)=1.17 (95\% CI= 0.37-3.70); RR(high)=3.13 (95\% CI= 1.17-8.39)). Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.}, address = {Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy.}, author = {Bonassi, Stefano and Norppa, Hannu and Ceppi, Marcello and Stromberg, Ulf and Vermeulen, Roel and Znaor, Ariana and Cebulska-Wasilewska, Antonina and Fabianova, Eleonora and Fucic, Alexandra and Gundy, Sarolta and Hansteen, Inger-Lise L. and Knudsen, Lisbeth E E. and Lazutka, Juozas and Rossner, Pavel and Sram, Radim J J. and Boffetta, Paolo }, citeulike-article-id = {2757866}, issn = {1460-2180}, journal = {Carcinogenesis}, keywords = {aberrations, cancerrisk, chromosome, lymphocytes}, month = {March}, posted-at = {2008-05-05 14:16:29}, priority = {3}, title = {Chromosomal Aberration Frequency in Lymphocytes Predicts the Risk of Cancer: Results from a Pooled Cohort Study of 22,358 Subjects in 11 Countries.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18356148}, year = {2008} }

TY - JOUR ID - citeulike:2757866 L3 - citeulike-article-id:2757866 TI - Chromosomal Aberration Frequency in Lymphocytes Predicts the Risk of Cancer: Results from a Pooled Cohort Study of 22,358 Subjects in 11 Countries. JF - Carcinogenesis AD - Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy. SN - 1460-2180 N2 - Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies which associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22,358 cancer free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium (RR = 1.31; 95% confidence interval (CI) 1.07-1.60) and in the high (RR = 1.41; 95% CI 1.16-1.72) tertiles, when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI= 1.34-3.68). The strongest association was found for stomach cancer (RR(medium)=1.17 (95% CI= 0.37-3.70); RR(high)=3.13 (95% CI= 1.17-8.39)). Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type. KW - aberrations KW - cancerrisk KW - chromosome KW - lymphocytes AU - Bonassi, Stefano AU - Norppa, Hannu AU - Ceppi, Marcello AU - Stromberg, Ulf AU - Vermeulen, Roel AU - Znaor, Ariana AU - Cebulska-Wasilewska, Antonina AU - Fabianova, Eleonora AU - Fucic, Alexandra AU - Gundy, Sarolta AU - Hansteen, Inger-Lise AU - Knudsen, Lisbeth E AU - Lazutka, Juozas AU - Rossner, Pavel AU - Sram, Radim J AU - Boffetta, Paolo PY - 2008/03/19/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18356148 ER -