Informativeness of Genetic Markers for Inference of Ancestry

@article{Rosenberg2003b, abstract = {Inference of individual ancestry is useful in various applications, such as admixture mapping and structured-association mapping. Using information-theoretic principles, we introduce a general measure, the informativeness for assignment (In), applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual ancestry. In a worldwide human microsatellite data set, we identify markers of highest informativeness for inference of regional ancestry and for inference of population ancestry within regions; these markers, which are listed in online-only tables in our article, can be useful both in testing for and in controlling the influence of ancestry on case-control genetic association studies. Markers that are informative in one collection of source populations are generally informative in others. Informativeness of random dinucleotides, the most informative class of microsatellites, is five to eight times that of random single-nucleotide polymorphisms (SNPs), but 2\%ndash12\% of SNPs have higher informativeness than the median for dinucleotides. Our results can aid in decisions about the type, quantity, and specific choice of markers for use in studies of ancestry.}, author = {Rosenberg, Noah A. and Li, Lei M. and Ward, Ryk and Pritchard, Jonathan K. }, citeulike-article-id = {1776113}, doi = {10.1086/380416}, journal = {American Journal of Human Genetics}, keywords = {methods, review, snp, str, structure}, pages = {1402--1422}, posted-at = {2007-10-16 20:35:02}, priority = {2}, title = {Informativeness of Genetic Markers for Inference of Ancestry}, url = {http://www.journals.uchicago.edu/cgi-bin/resolve?id=doi:10.1086/380416}, volume = {73}, year = {2003} }

TY - JOUR ID - Rosenberg2003b L3 - citeulike-article-id:1776113 TI - Informativeness of Genetic Markers for Inference of Ancestry JF - American Journal of Human Genetics VL - 73 SP - 1402 EP - 1422 N2 - Inference of individual ancestry is useful in various applications, such as admixture mapping and structured-association mapping. Using information-theoretic principles, we introduce a general measure, the informativeness for assignment (In), applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual ancestry. In a worldwide human microsatellite data set, we identify markers of highest informativeness for inference of regional ancestry and for inference of population ancestry within regions; these markers, which are listed in online-only tables in our article, can be useful both in testing for and in controlling the influence of ancestry on case-control genetic association studies. Markers that are informative in one collection of source populations are generally informative in others. Informativeness of random dinucleotides, the most informative class of microsatellites, is five to eight times that of random single-nucleotide polymorphisms (SNPs), but 2%ndash12% of SNPs have higher informativeness than the median for dinucleotides. Our results can aid in decisions about the type, quantity, and specific choice of markers for use in studies of ancestry. KW - methods KW - review KW - snp KW - str KW - structure AU - Rosenberg, Noah AU - Li, Lei AU - Ward, Ryk AU - Pritchard, Jonathan PY - 2003/// UR - http://www.journals.uchicago.edu/cgi-bin/resolve?id=doi:10.1086/380416 ER -