RNA dynamics: it is about time

@article{citeulike:2880197, abstract = {Many recently discovered RNA functions rely on highly complex multistep conformational transitions that occur in response to an array of cellular signals. These dynamics accompany and guide, for example, RNA cotranscriptional folding, ligand sensing and signaling, site-specific catalysis in ribozymes, and the hierarchically ordered assembly of ribonucleoproteins. RNA dynamics are encoded by both the inherent properties of RNA structure, spanning many motional modes with a large range of amplitudes and timescales, and external trigger factors, ranging from proteins, nucleic acids, metal ions, metabolites, and vitamins to temperature and even directional RNA biosynthesis itself. Here, we review recent advances in our understanding of RNA dynamics as highlighted by biophysical tools.}, author = {Al-Hashimi, Hashim M. and Walter, Nils G. }, citeulike-article-id = {2880197}, doi = {10.1016/j.sbi.2008.04.004}, journal = {Current Opinion in Structural Biology}, keywords = {rna}, posted-at = {2008-06-10 17:09:24}, priority = {2}, title = {RNA dynamics: it is about time}, url = {http://dx.doi.org/10.1016/j.sbi.2008.04.004}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:2880197 L3 - citeulike-article-id:2880197 TI - RNA dynamics: it is about time JF - Current Opinion in Structural Biology VL - In Press, Corrected Proof N2 - Many recently discovered RNA functions rely on highly complex multistep conformational transitions that occur in response to an array of cellular signals. These dynamics accompany and guide, for example, RNA cotranscriptional folding, ligand sensing and signaling, site-specific catalysis in ribozymes, and the hierarchically ordered assembly of ribonucleoproteins. RNA dynamics are encoded by both the inherent properties of RNA structure, spanning many motional modes with a large range of amplitudes and timescales, and external trigger factors, ranging from proteins, nucleic acids, metal ions, metabolites, and vitamins to temperature and even directional RNA biosynthesis itself. Here, we review recent advances in our understanding of RNA dynamics as highlighted by biophysical tools. KW - rna AU - Al-Hashimi, Hashim AU - Walter, Nils UR - http://dx.doi.org/10.1016/j.sbi.2008.04.004 ER -