Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.

@article{citeulike:2144602, abstract = {Maternal antibodies protect newborns whilst they are immunologically immature. This study shows that maternal antibodies can also shape the B cell repertoire of the offspring long after the maternal antibodies themselves become undetectable. V(H)DJ(H) gene-targeted (VI10) mice expressing a heavy chain specific for vesicular stomatitis virus (VSV) produce a 20-fold increased spontaneous titer of VSV-neutralizing antibodies. When transferred from mother to offspring, these antibodies prevented accumulation of Ag-specific transitional type 2 and marginal zone B cells with an activated phenotype and favored selection to the B cell follicles. This effect was B cell-intrinsic and lasted up to adulthood. The pups nursed by mothers producing specific antibodies developed higher endogenous antibody titers of this specificity which perpetuated the effects of specific B cell selection into the mature follicular compartment, presumably by blocking auto-Ag-dependent development of transitional type 2 B cells in the spleen. This repertoire change was functional, as following infection of adult mice with VSV, those pups that had received specific maternal antibodies as neonates had increased pre-immune titers and mounted strong early IgG neutralizing antibodies.}, address = {Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland.}, author = {Fink, Katja and Zellweger, Raphael and Weber, Jacqueline and Manjarrez-Orduno, Nataly and Holdener, Martin and Senn, Beatrice M M. and Hengartner, Hans and Zinkernagel, Rolf M M. and Macpherson, Andrew J J. }, citeulike-article-id = {2144602}, doi = {10.1002/eji.200737872}, issn = {0014-2980}, journal = {Eur J Immunol}, keywords = {antibody, epigenetics, immunity, immunology, inheritance, maternal, virus}, month = {December}, posted-at = {2007-12-19 08:16:14}, priority = {2}, title = {Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.}, url = {http://dx.doi.org/10.1002/eji.200737872}, year = {2007} }

TY - JOUR ID - citeulike:2144602 L3 - citeulike-article-id:2144602 TI - Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies. JF - Eur J Immunol AD - Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland. SN - 0014-2980 N2 - Maternal antibodies protect newborns whilst they are immunologically immature. This study shows that maternal antibodies can also shape the B cell repertoire of the offspring long after the maternal antibodies themselves become undetectable. V(H)DJ(H) gene-targeted (VI10) mice expressing a heavy chain specific for vesicular stomatitis virus (VSV) produce a 20-fold increased spontaneous titer of VSV-neutralizing antibodies. When transferred from mother to offspring, these antibodies prevented accumulation of Ag-specific transitional type 2 and marginal zone B cells with an activated phenotype and favored selection to the B cell follicles. This effect was B cell-intrinsic and lasted up to adulthood. The pups nursed by mothers producing specific antibodies developed higher endogenous antibody titers of this specificity which perpetuated the effects of specific B cell selection into the mature follicular compartment, presumably by blocking auto-Ag-dependent development of transitional type 2 B cells in the spleen. This repertoire change was functional, as following infection of adult mice with VSV, those pups that had received specific maternal antibodies as neonates had increased pre-immune titers and mounted strong early IgG neutralizing antibodies. KW - antibody KW - epigenetics KW - immunity KW - immunology KW - inheritance KW - maternal KW - virus AU - Fink, Katja AU - Zellweger, Raphael AU - Weber, Jacqueline AU - Manjarrez-Orduno, Nataly AU - Holdener, Martin AU - Senn, Beatrice M AU - Hengartner, Hans AU - Zinkernagel, Rolf M AU - Macpherson, Andrew J PY - 2007/12/14/ UR - http://dx.doi.org/10.1002/eji.200737872 ER -