From genes to protein structure and function: Novel applications of computational approaches in the genomic era.

by: J Skolnick, JS Fetrow

Trends Biotechnol, Vol. 18, No. 1. (January 2000), pp. 34-39.

View FullText article

Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

robert, rsantana

Find related articles with these CiteULike tags

bioinformatics, protein, structure-function

Abstract

The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just knowing the structure of the protein is also insufficient for prediction of multiple functional sites. Structural descriptors for protein functional sites are crucial for unlocking the secrets in both the sequence and structural-genomics projects.

@article{citeulike:1135769, abstract = {The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just knowing the structure of the protein is also insufficient for prediction of multiple functional sites. Structural descriptors for protein functional sites are crucial for unlocking the secrets in both the sequence and structural-genomics projects.}, address = {Danforth Plant Science Center, Laboratory of Computational Genomics, St Louis, MO 63108, USA. skolnick@danforthcenter.org}, author = {Skolnick, J. and Fetrow, J. S. }, citeulike-article-id = {1135769}, issn = {0167-7799}, journal = {Trends Biotechnol}, keywords = {bioinformatics, structure-function}, month = {January}, number = {1}, pages = {34--39}, posted-at = {2007-03-02 09:47:17}, priority = {2}, title = {From genes to protein structure and function: {N}ovel applications of computational approaches in the genomic era.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10631780}, volume = {18}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:1135769 L3 - citeulike-article-id:1135769 TI - From genes to protein structure and function: {N}ovel applications of computational approaches in the genomic era. JF - Trends Biotechnol VL - 18 IS - 1 SP - 34 EP - 39 AD - Danforth Plant Science Center, Laboratory of Computational Genomics, St Louis, MO 63108, USA. skolnick@danforthcenter.org SN - 0167-7799 N2 - The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just knowing the structure of the protein is also insufficient for prediction of multiple functional sites. Structural descriptors for protein functional sites are crucial for unlocking the secrets in both the sequence and structural-genomics projects. KW - bioinformatics KW - structure-function AU - Skolnick, J AU - Fetrow, JS PY - 2000/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/10631780 ER -

RIS BibTeX