Alternative trans-splicing: a novel mode of pre-mRNA processing.

by: T Horiuchi, T Aigaki

Biol Cell, Vol. 98, No. 2. (February 2006), pp. 135-140.

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Abstract

Alternative splicing is an important process contributing to proteome diversity without involving an increase in the number of genes. In some cases, alternative splicing is carried out under 'trans-mode', called alternative trans-splicing, in which exons located on separate pre-mRNA molecules are selectively joined to produce mature mRNAs encoding proteins with distinct structures and functions. However, it is not known how widespread or how frequently trans-splicing occurs in vivo. Recently, trans-allelic trans-splicing has been unambiguously demonstrated in Drosophila using a SNP (single nucleotide polymorphism) as a marker. In this review, we provide an overview of alternative trans-splicing in Drosophila and mammals, and discuss its mechanisms.

@article{citeulike:642602, abstract = {Alternative splicing is an important process contributing to proteome diversity without involving an increase in the number of genes. In some cases, alternative splicing is carried out under 'trans-mode', called alternative trans-splicing, in which exons located on separate pre-mRNA molecules are selectively joined to produce mature mRNAs encoding proteins with distinct structures and functions. However, it is not known how widespread or how frequently trans-splicing occurs in vivo. Recently, trans-allelic trans-splicing has been unambiguously demonstrated in Drosophila using a SNP (single nucleotide polymorphism) as a marker. In this review, we provide an overview of alternative trans-splicing in Drosophila and mammals, and discuss its mechanisms.}, address = {Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minami-osawa, Hachioji-shi, Tokyo 192-0397, Japan.}, author = {Horiuchi, T. and Aigaki, T. }, citeulike-article-id = {642602}, doi = {10.1042/BC20050002}, issn = {0248-4900}, journal = {Biol Cell}, keywords = {rna, trans-splicing}, month = {February}, number = {2}, pages = {135--140}, posted-at = {2006-05-18 04:09:39}, priority = {2}, title = {Alternative trans-splicing: a novel mode of pre-mRNA processing.}, url = {http://dx.doi.org/10.1042/BC20050002}, volume = {98}, year = {2006} }

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TY - JOUR ID - citeulike:642602 L3 - citeulike-article-id:642602 TI - Alternative trans-splicing: a novel mode of pre-mRNA processing. JF - Biol Cell VL - 98 IS - 2 SP - 135 EP - 140 AD - Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minami-osawa, Hachioji-shi, Tokyo 192-0397, Japan. SN - 0248-4900 N2 - Alternative splicing is an important process contributing to proteome diversity without involving an increase in the number of genes. In some cases, alternative splicing is carried out under 'trans-mode', called alternative trans-splicing, in which exons located on separate pre-mRNA molecules are selectively joined to produce mature mRNAs encoding proteins with distinct structures and functions. However, it is not known how widespread or how frequently trans-splicing occurs in vivo. Recently, trans-allelic trans-splicing has been unambiguously demonstrated in Drosophila using a SNP (single nucleotide polymorphism) as a marker. In this review, we provide an overview of alternative trans-splicing in Drosophila and mammals, and discuss its mechanisms. KW - rna KW - trans-splicing AU - Horiuchi, T AU - Aigaki, T PY - 2006/02// UR - http://dx.doi.org/10.1042/BC20050002 ER -

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