The estimation of population differentiation with microsatellite markers

@article{citeulike:893706, abstract = {Abstract Microsatellite markers are routinely used to investigate the genetic structuring of natural populations. The knowledge of how genetic variation is partitioned among populations may have important implications not only in evolutionary biology and ecology, but also in conservation biology. Hence, reliable estimates of population differentiation are crucial to understand the connectivity among populations and represent important tools to develop conservation strategies. The estimation of differentiation is c from Wright's FST and/or Slatkin's RST, an FST-analogue assuming a stepwise mutation model. Both these statistics have their drawbacks. Furthermore, there is no clear consensus over their relative accuracy. In this review, we first discuss the consequences of different temporal and spatial sampling strategies on differentiation estimation. Then, we move to statistical problems directly associated with the estimation of population structuring itself, with particular emphasis on the effects of high mutation rates and mutation patterns of microsatellite loci. Finally, we discuss the biological interpretation of population structuring estimates.}, author = {Balloux, Francois and Lugon-Moulin, Nicolas }, citeulike-article-id = {893706}, doi = {10.1046/j.0962-1083.2001.01436.x}, journal = {Molecular Ecology}, keywords = {fst, review, rst, stepwisemodel}, number = {2}, pages = {155--165}, posted-at = {2006-10-12 01:35:19}, priority = {4}, title = {The estimation of population differentiation with microsatellite markers}, url = {http://www.blackwell-synergy.com/doi/abs/10.1046/j.0962-1083.2001.01436.x}, volume = {11}, year = {2002} }

TY - JOUR ID - citeulike:893706 L3 - citeulike-article-id:893706 TI - The estimation of population differentiation with microsatellite markers JF - Molecular Ecology VL - 11 IS - 2 SP - 155 EP - 165 N2 - Abstract Microsatellite markers are routinely used to investigate the genetic structuring of natural populations. The knowledge of how genetic variation is partitioned among populations may have important implications not only in evolutionary biology and ecology, but also in conservation biology. Hence, reliable estimates of population differentiation are crucial to understand the connectivity among populations and represent important tools to develop conservation strategies. The estimation of differentiation is c from Wright's FST and/or Slatkin's RST, an FST-analogue assuming a stepwise mutation model. Both these statistics have their drawbacks. Furthermore, there is no clear consensus over their relative accuracy. In this review, we first discuss the consequences of different temporal and spatial sampling strategies on differentiation estimation. Then, we move to statistical problems directly associated with the estimation of population structuring itself, with particular emphasis on the effects of high mutation rates and mutation patterns of microsatellite loci. Finally, we discuss the biological interpretation of population structuring estimates. KW - fst KW - review KW - rst KW - stepwisemodel AU - Balloux, Francois AU - Lugon-Moulin, Nicolas PY - 2002/// UR - http://www.blackwell-synergy.com/doi/abs/10.1046/j.0962-1083.2001.01436.x ER -