Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

@article{citeulike:400019, abstract = {The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia.}, address = {Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.}, author = {Tybulewicz, V. L. and Crawford, C. E. and Jackson, P. K. and Bronson, R. T. and Mulligan, R. C. }, citeulike-article-id = {400019}, issn = {0092-8674}, journal = {Cell}, keywords = {abl, tcrmr}, month = {June}, number = {7}, pages = {1153--1163}, posted-at = {2005-11-18 15:18:17}, priority = {2}, title = {Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2065352}, volume = {65}, year = {1991} }

TY - JOUR ID - citeulike:400019 L3 - citeulike-article-id:400019 TI - Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. JF - Cell VL - 65 IS - 7 SP - 1153 EP - 1163 AD - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142. SN - 0092-8674 N2 - The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia. KW - abl KW - tcrmr AU - Tybulewicz, VL AU - Crawford, CE AU - Jackson, PK AU - Bronson, RT AU - Mulligan, RC PY - 1991/06/28/ UR - http://view.ncbi.nlm.nih.gov/pubmed/2065352 ER -