Conservation of small RNA pathways in platypus

@article{citeulike:2790136, abstract = {Small RNA pathways play evolutionarily conserved roles in gene regulation and defense from parasitic nucleic acids. The character and expression patterns of small RNAs show conservation throughout animal lineages, but specific animal clades also show variations on these recurring themes, including species-specific small RNAs. The monotremes, with only platypus and four species of echidna as extant members, represent the basal branch of the mammalian lineage. Here, we examine the small RNA pathways of monotremes by deep sequencing of six platypus and echidna tissues. We find that highly conserved microRNA species display their signature tissue-specific expression patterns. In addition, we find a large rapidly evolving cluster of microRNAs on platypus chromosome X1, which is unique to monotremes. Platypus and echidna testes contain a robust Piwi-interacting (piRNA) system, which appears to be participating in ongoing transposon defense. 10.1101/gr.073056.107}, author = {Murchison, Elizabeth P. and Kheradpour, Pouya and Sachidanandam, Ravi and Smith, Carly and Hodges, Emily and Xuan, Zhenyu and Kellis, Manolis and Grutzner, Frank and Stark, Alexander and Hannon, Gregory J. }, citeulike-article-id = {2790136}, doi = {10.1101/gr.073056.107}, journal = {Genome Res.}, month = {May}, pages = {gr.073056.107+}, posted-at = {2008-06-16 12:56:48}, priority = {2}, title = {Conservation of small RNA pathways in platypus}, url = {http://dx.doi.org/10.1101/gr.073056.107}, year = {2008} }

TY - JOUR ID - citeulike:2790136 L3 - citeulike-article-id:2790136 TI - Conservation of small RNA pathways in platypus JF - Genome Res. SP - gr.073056.107 N2 - Small RNA pathways play evolutionarily conserved roles in gene regulation and defense from parasitic nucleic acids. The character and expression patterns of small RNAs show conservation throughout animal lineages, but specific animal clades also show variations on these recurring themes, including species-specific small RNAs. The monotremes, with only platypus and four species of echidna as extant members, represent the basal branch of the mammalian lineage. Here, we examine the small RNA pathways of monotremes by deep sequencing of six platypus and echidna tissues. We find that highly conserved microRNA species display their signature tissue-specific expression patterns. In addition, we find a large rapidly evolving cluster of microRNAs on platypus chromosome X1, which is unique to monotremes. Platypus and echidna testes contain a robust Piwi-interacting (piRNA) system, which appears to be participating in ongoing transposon defense. 10.1101/gr.073056.107 AU - Murchison, Elizabeth AU - Kheradpour, Pouya AU - Sachidanandam, Ravi AU - Smith, Carly AU - Hodges, Emily AU - Xuan, Zhenyu AU - Kellis, Manolis AU - Grutzner, Frank AU - Stark, Alexander AU - Hannon, Gregory PY - 2008/05/07/ UR - http://dx.doi.org/10.1101/gr.073056.107 ER -