Getting connected: analysis and principles of biological networks.

by: X Zhu, M Gerstein, M Snyder

Genes Dev, Vol. 21, No. 9. (1 May 2007), pp. 1010-1024.

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Abstract

The execution of complex biological processes requires the precise interaction and regulation of thousands of molecules. Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks. These biological networks are significantly different from random networks and often exhibit ubiquitous properties in terms of their structure and organization. Analyzing these networks provides novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies.

@article{citeulike:1314172, abstract = {The execution of complex biological processes requires the precise interaction and regulation of thousands of molecules. Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks. These biological networks are significantly different from random networks and often exhibit ubiquitous properties in terms of their structure and organization. Analyzing these networks provides novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies.}, address = {Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA;}, author = {Zhu, X. and Gerstein, M. and Snyder, M. }, citeulike-article-id = {1314172}, doi = {http://dx.doi.org/10.1101/gad.1528707}, issn = {0890-9369}, journal = {Genes Dev}, keywords = {bioinformatics, network, systems}, month = {May}, number = {9}, pages = {1010--1024}, posted-at = {2008-06-19 20:11:13}, priority = {5}, title = {Getting connected: analysis and principles of biological networks.}, url = {http://dx.doi.org/10.1101/gad.1528707}, volume = {21}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1314172 L3 - citeulike-article-id:1314172 TI - Getting connected: analysis and principles of biological networks. JF - Genes Dev VL - 21 IS - 9 SP - 1010 EP - 1024 AD - Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA; SN - 0890-9369 N2 - The execution of complex biological processes requires the precise interaction and regulation of thousands of molecules. Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks. These biological networks are significantly different from random networks and often exhibit ubiquitous properties in terms of their structure and organization. Analyzing these networks provides novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies. KW - bioinformatics KW - network KW - systems AU - Zhu, X AU - Gerstein, M AU - Snyder, M PY - 2007/05/01/ UR - http://dx.doi.org/10.1101/gad.1528707 ER -

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