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ramensky library [151 articles]

最近 ramensky さんのライブラリ .
  • Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
    The Journal of biological chemistry, Vol. 280, No. 35. (2 September 2005), pp. 30949-30955.
    by H Wang, Y Liu, Y Chen, H Robinson, H Ke
    posted to selective_binding drug_design by ramensky on 2008-07-16 17:22:42 as **
  • Proportionally more deleterious genetic variation in European than in African populations
    Nature, Vol. 451, No. 7181. (21 February 2008), pp. 994-997.
    by Kirk E Lohmueller, Amit R Indap, Steffen Schmidt, Adam R Boyko, Ryan D Hernandez, Melissa J Hubisz, John J Sninsky, Thomas J White, Shamil R Sunyaev, Rasmus Nielsen, Andrew G Clark, Carlos D Bustamante
    posted to nssnps association_studies by ramensky on 2008-07-04 14:19:18 as ** along with 3 people and 1 group djkt caseybrown mailund Fasting, food and evolution
  • In silico prediction of the deleterious effect of a mutation: proceed with caution in clinical genetics.
    Clin Chem, Vol. 50, No. 11. (November 2004), pp. 1974-1978.
    by D Tchernitchko, M Goossens, H Wajcman
    posted to nssnps by ramensky on 2008-06-24 00:20:35 as ** along with 1 person chrn
  • Screening for Deleterious Nonsynonymous Single-Nucleotide Polymorphisms in Genes Involved in Steroid Hormone Metabolism and Response
    Cancer Epidemiol Biomarkers Prev, Vol. 14, No. 5. (1 May 2005), pp. 1326-1329.
    by Melissa M Johnson, John Houck, Chu Chen
    posted to nssnps by ramensky on 2008-06-24 00:17:51 as ** along with 1 person Run7
  • Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).
    Pharmacogenet Genomics, Vol. 15, No. 9. (September 2005), pp. 647-657.
    by IJ Létourneau, RG Deeley, SP Cole
    posted to personalized_medicine nssnps by ramensky on 2008-06-23 22:42:29 as ** along with 1 person happy_manatee
  • The structure of common genetic variation in United States populations.
    Am J Hum Genet, Vol. 81, No. 6. (December 2007), pp. 1221-1231.
    by SL Guthery, BA Salisbury, MS Pungliya, JC Stephens, M Bamshad
    posted to population_genetics association_studies by ramensky on 2008-06-19 21:24:13 as ** along with 1 person jyuh
  • Heritability of alternative splicing in the human genome
    Genome Res., Vol. 17, No. 8. (1 August 2007), pp. 1210-1218.
    by Tony Kwan, David Benovoy, Christel Dias, Scott Gurd, David Serre, Harry Zuzan, Tyson A Clark, Anthony Schweitzer, Michelle K Staples, Hui Wang, John E Blume, Thomas J Hudson, Rob Sladek, Jacek Majewski
    posted to alternative_splicing by ramensky on 2008-06-16 21:37:09 as ** along with 6 people and 3 groups jo_davies nicholso dchughes xingxu msomel caseybrown Bioinformatics G4ID Genetics-of-Gambling
  • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Nature, Vol. 447, No. 7145. (7 June 2007), pp. 661-678.
    posted to association_studies by ramensky on 2008-06-16 21:31:41 as ** along with 20 people and 3 groups balicea wenhui raiyar jyuh jfr yas hpiwowar larios vplagnol frohike qmwwallace joepickrell massivemayhem Garamonfok PredictER hms jo_davies psique caseybrown mcgannd parkinson's disease references Bioinformatics T_lab
  • notes Genome-wide survey of allele-specific splicing in humans
    BMC Genomics, Vol. 9 (02 June 2008), 265.
    by Victoria Nembaware, Bukiwe Lupindo, Katherine Schouest, Charles Spillane, Konrad Scheffler, Cathal Seoighe
    posted to alternative_splicing by ramensky on 2008-06-16 21:28:07 as **
  • The Molecular Biology Database Collection: 2008 update
    Nucl. Acids Res. (19 November 2007), gkm1037.
    by Michael Y Galperin
    posted to misc by ramensky on 2008-05-27 23:32:56 as ** along with 5 people and 1 group AlexanderPico higueruelo moborg dullhunk jmrivort G-quadruplex
  • SNP-SNP interactions in breast cancer susceptibility.
    BMC cancer, Vol. 6 (2006)
    by VU Onay, L Briollais, JA Knight, E Shi, Y Wang, S Wells, H Li, I Rajendram, IL Andrulis, H Ozcelik
    posted to cancer by ramensky on 2008-05-27 21:46:38 as **
  • Can we rationally design promiscuous drugs?
    Curr Opin Struct Biol (24 January 2006)
    by Andrew L L Hopkins, Jonathan S S Mason, John P P Overington
    posted to drug_design by ramensky on 2008-05-15 00:34:20 as ** along with 5 people and 1 group BragilMassoud apaydin kuhn bicko yongzhao TSRI_MGL
  • How many drug targets are there?
    Nature Reviews Drug Discovery, Vol. 5, No. 12., pp. 993-996.
    by John P Overington, Bissan Al-Lazikani, Andrew L Hopkins
    posted to drug_design by ramensky on 2008-05-15 00:33:35 as ** along with 7 people and 1 group higueruelo srp33 BragilMassoud cannin kuhn bicko mingzhi libr
  • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    Nature Genetics, Vol. 37, No. 6. (22 May 2005), pp. 590-592.
    by Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert HJ Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Siu T Yuen, Andrew G Nicholson, Sunil Lakhani, Douglas F Easton, Barbara L Weber, Michael R Stratton, Andrew A Futreal, Richard Wooster
    posted to cancer by ramensky on 2008-04-29 20:34:07 as ** along with 1 person cerami
  • Somatic mutations of the protein kinase gene family in human lung cancer.
    Cancer research, Vol. 65, No. 17. (1 September 2005), pp. 7591-7595.
    by H Davies, C Hunter, R Smith, P Stephens, C Greenman, G Bignell, J Teague, A Butler, S Edkins, C Stevens, A Parker, S O'Meara, T Avis, S Barthorpe, L Brackenbury, G Buck, J Clements, J Cole, E Dicks, K Edwards, S Forbes, M Gorton, K Gray, K Halliday, R Harrison, K Hills, J Hinton, D Jones, V Kosmidou, R Laman, R Lugg, A Menzies, J Perry, R Petty, K Raine, R Shepherd, A Small, H Solomon, Y Stephens, C Tofts, J Varian, A Webb, S West, S Widaa, A Yates, F Brasseur, CS Cooper, AM Flanagan, A Green, M Knowles, SY Leung, LH Looijenga, B Malkowicz, MA Pierotti, BT Teh, ST Yuen, SR Lakhani, DF Easton, BL Weber, P Goldstraw, AG Nicholson, R Wooster, MR Stratton, PA Futreal
    posted to cancer by ramensky on 2008-04-29 20:30:53 as **
  • Cancer: Drivers and passengers
    Nature, Vol. 446, No. 7132. (07 March 2007), pp. 145-146.
    by Daniel A Haber, Jeff Settleman
    posted to cancer by ramensky on 2008-04-29 20:29:38 as ** along with 4 people and 3 groups cerami dchughes ealloza Garamonfok G4ID BioinfoCIPF Genetics-of-Gambling
  • Patterns of somatic mutation in human cancer genomes
    Nature, Vol. 446, No. 7132., pp. 153-158.
    by Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O’meara, Imre Vastrik, Esther E Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P Cahill, David N Louis, Peter Goldstraw, Andrew G Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L Weber, Yoke-Eng Chiew, Anna Defazio, Mel F Greaves, Anthony R Green, Peter Campbell, Ewan Birney, Douglas F Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok K Khoo, Bin T Teh, Siu T Yuen, Suet Y Leung, Richard Wooster, Andrew P Futreal, Michael R Stratton
    posted to cancer by ramensky on 2008-04-29 20:25:24 as ** along with 9 people cerami frohike Petersarkies kentsis jfr massivemayhem efge Garamonfok daed
  • Comparative lesion sequencing provides insights into tumor evolution
    Proceedings of the National Academy of Sciences, Vol. 105, No. 11. (18 March 2008), pp. 4283-4288.
    by Sian Jones, Wei-Dong Chen, Giovanni Parmigiani, Frank Diehl, Niko Beerenwinkel, Tibor Antal, Arne Traulsen, Martin A Nowak, Christopher Siegel, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Joseph Willis, Sanford D Markowitz
    posted to cancer by ramensky on 2008-04-22 13:11:20 as **
  • The complete genome of an individual by massively parallel DNA sequencing
    Nature, Vol. 452, No. 7189. (17 April 2008), pp. 872-876.
    by David A Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy Mcguire, Wen He, Yi-Ju Chen, Vinod Makhijani, Thomas G Roth, Xavier Gomes, Karrie Tartaro, Faheem Niazi, Cynthia L Turcotte, Gerard P Irzyk, James R Lupski, Craig Chinault, Xing-Zhi Song, Yue Liu, Ye Yuan, Lynne Nazareth, Xiang Qin, Donna M Muzny, Marcel Margulies, George M Weinstock, Richard A Gibbs, Jonathan M Rothberg
    posted to nssnps by ramensky on 2008-04-20 15:49:08 as ** along with 11 people and 2 groups jyuh Neeperando dbensasson Huub_odc bpb orzenil dullhunk djkt psique caseybrown melting microbiology_nijmegen parkinson's disease references
  • Natural selection of protein structural and functional properties: a SNP perspective
    Genome Biology, Vol. 9, No. 4. (2008)
    by Jinfeng Liu, Yan Zhang, Xingye Lei, Zemin Zhang
    posted to nssnps by ramensky on 2008-04-12 12:56:16 as ** along with 4 people and 1 group operon fernan stajich dandaman Berkeley Mycology
  • Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
    Science, Vol. 312, No. 5770. (7 April 2006), pp. 111-114.
    by Daniel M Weinreich, Nigel F Delaney, Mark A Depristo, Daniel L Hartl
    posted to adaptation by ramensky on 2008-04-12 12:38:37 as ** along with 13 people and 5 groups stevanspringer barry pansapiens imouthesmp dayjm Einat marcius i41m nirfriedman cmm RowanBarrett Vaquero Ema structural_bioinformatics Bioinformatics FAB-lab BioinfoCIPF SGU-CIPF
  • Missense meanderings in sequence space: a biophysical view of protein evolution
    Nature Reviews Genetics, Vol. 6, No. 9. (01 September 2005), pp. 678-687.
    by Mark A Depristo, Daniel M Weinreich, Daniel L Hartl
    posted to adaptation evolution by ramensky on 2008-04-12 12:36:15 as ** along with 2 people rklancer monod
  • Experimental Evolution Yields Hundreds of Mutations in a Functional Viral Genome
    Journal of Molecular Evolution, Vol. 57, No. 3. (2003), pp. 241-248.
    by JJ Bull, MR Badgett, D Rokyta, IJ Molineux
    posted to adaptation by ramensky on 2008-04-09 17:54:01 as **
  • Fitness effects of beneficial mutations: the mutational landscape model in experimental evolution
    Current Opinion in Genetics & Development, Vol. In Press, Corrected Proof
    by Andrea J Betancourt, Jonathan P Bollback
    posted to adaptation by ramensky on 2008-04-09 16:50:25 as ** along with 2 people stevanspringer jmeppley
  • Distributions of epistasis in microbes fit predictions from a fitness landscape model
    Nature Genetics, Vol. 39, No. 4. (18 March 2007), pp. 555-560.
    by Guillaume Martin, Santiago F Elena, Thomas Lenormand
    posted to adaptation by ramensky on 2008-04-09 16:48:59 as **
  • Mutational Reversions During Adaptive Protein Evolution
    Mol Biol Evol (7 June 2007), msm118.
    by Mark A Depristo, Daniel L Hartl, Daniel M Weinreich
    posted to adaptation by ramensky on 2008-04-09 16:45:30 as ** along with 1 person cjeans
  • Analysis of epistatic interactions and fitness landscapes using a new geometric approach
    BMC Evolutionary Biology, Vol. 7 (13 April 2007), 60.
    by Niko Beerenwinkel, Lior Pachter, Bernd Sturmfels, Santiago F Elena, Richard E Lenski
    posted to cpds by ramensky on 2008-04-09 16:37:34 as ** along with 5 people pszw piaszw Ayest msierk elm
  • The Many Roles of Computation in Drug Discovery
    Science, Vol. 303, No. 5665. (19 March 2004), pp. 1813-1818.
    by William L Jorgensen
    posted to drug_design by ramensky on 2008-03-31 17:59:31 as ** along with 8 people dgruiz kuhn balicea blackbart euan junehlee onufriev ashaytan
  • Novel technologies for virtual screening.
    Drug Discov Today, Vol. 9, No. 1. (1 January 2004), pp. 27-34.
    by T Lengauer, C Lemmen, M Rarey, M Zimmermann
    posted to drug_design by ramensky on 2008-03-31 17:47:44 as ** along with 2 people and 2 groups tjimenez sangeetha Bioinformatics insilicodrug
  • Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors.
    Cold Spring Harb Symp Quant Biol, Vol. 70 (2005), pp. 73-81.
    by RK Thomas, H Greulich, Y Yuza, JC Lee, T Tengs, W Feng, TH Chen, E Nickerson, J Simons, M Egholm, JM Rothberg, WR Sellers, ML Meyerson
    posted to cancer personalized_medicine by ramensky on 2008-03-30 20:26:07 as **
  • notes sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank.
    J Chem Inf Model, Vol. 46, No. 2. (r 2006), pp. 717-727.
    by E Kellenberger, P Muller, C Schalon, G Bret, N Foata, D Rognan
    posted to drug_design by ramensky on 2008-03-27 13:24:01 as ** along with 5 people and 1 group sim82 BragilMassoud caporaso schlauchi daevans biomedical-nlp
  • A new test set for validating predictions of protein-ligand interaction.
    Proteins, Vol. 49, No. 4. (1 December 2002), pp. 457-471.
    by JW Nissink, C Murray, M Hartshorn, ML Verdonk, JC Cole, R Taylor
    posted to drug_design validation by ramensky on 2008-03-26 14:31:04 as ** along with 3 people and 1 group BragilMassoud yongzhao blackbart TSRI_MGL
  • Case histories, magic bullets and the state of drug discovery
    Nature Reviews Drug Discovery, Vol. 5, No. 8. (13 April 2006), pp. 635-640.
    by Jürgen Drews
    posted to drug_design by ramensky on 2008-03-24 13:33:22 as **
  • notes Therapeutic targets: progress of their exploration and investigation of their characteristics.
    Pharmacol Rev, Vol. 58, No. 2. (June 2006), pp. 259-279.
    by CJ Zheng, LY Han, CW Yap, ZL Ji, ZW Cao, YZ Chen
    posted to drug_design by ramensky on 2008-03-24 01:30:34 as **
  • ADMET--turning chemicals into drugs.
    Nat Biotechnol, Vol. 19, No. 8. (August 2001), pp. 722-726.
    by J Hodgson
    posted to drug_design by ramensky on 2008-03-24 01:25:09 as **
  • Drug discovery: a historical perspective.
    Science, Vol. 287, No. 5460. (17 March 2000), pp. 1960-1964.
    by J Drews
    posted to drug_design by ramensky on 2008-03-24 01:22:07 as ** along with 11 people and 5 groups yaredo srp33 Yanno BragilMassoud nachtalp kuhn Borelli sangeetha joergkurtwegner jdiggans LamBras Bioinformatics Molecular-Modelling Drug-Design Cheminformatics insilicodrug
  • THE DRUGGABLE GENOME
    Nat Rev Drug Discov, Vol. 1, No. 9. (2002), pp. 727-730.
    by Andrew L Hopkins, Colin R Groom
    posted to drug_design by ramensky on 2008-03-24 01:13:07 as ** along with 5 people and 2 groups Yanno andreasauerwein marcius Nambi happy_manatee BioinfoCIPF SGU-CIPF
  • Genotype, haplotype and copy-number variation in worldwide human populations
    Nature, Vol. 451, No. 7181. (21 February 2008), pp. 998-1003.
    by Mattias Jakobsson, Sonja W Scholz, Paul Scheet, Raphael J Gibbs, Jenna M Vanliere, Hon-Chung Fung, Zachary A Szpiech, James H Degnan, Kai Wang, Rita Guerreiro, Jose M Bras, Jennifer C Schymick, Dena G Hernandez, Bryan J Traynor, Javier Simon-Sanchez, Mar Matarin, Angela Britton, Joyce van de Leemput, Ian Rafferty, Maja Bucan, Howard M Cann, John A Hardy, Noah A Rosenberg, Andrew B Singleton
    posted to haplotypes population_genetics by ramensky on 2008-03-23 22:11:20 as ** along with 4 people and 1 group Archaeogenetics djkt mailund thomaskelder Fasting, food and evolution
  • Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
    Science, Vol. 319, No. 5866. (22 February 2008), pp. 1100-1104.
    by Jun Z Li, Devin M Absher, Hua Tang, Audrey M Southwick, Amanda M Casto, Sohini Ramachandran, Howard M Cann, Gregory S Barsh, Marcus Feldman, Luigi L Cavalli-Sforza, Richard M Myers
    posted to haplotypes population_genetics by ramensky on 2008-03-23 22:11:02 as ** along with 10 people Archaeogenetics adacier cgravlee echinotrix EsepBib zwang qwermish xingxu mailund Dorkins
  • Case Histories: Nature Reviews Drug Discovery, Article series
    Nature Reviews Drug Discovery
    posted to drug_design by ramensky on 2008-03-23 17:57:00 as **
  • A guide to drug discovery: Nature Reviews Drug Discovery, Article series
    Nature Reviews Drug Discovery
    posted to drug_design by ramensky on 2008-03-23 17:56:00 as **
  • Optimizing the use of open-source software applications in drug discovery
    Drug Discovery Today, Vol. 11, No. 3-4. (February 2006), pp. 127-132.
    by Werner J Geldenhuys, Kevin E Gaasch, Mark Watson, David D Allen, Cornelis J Van der Schyf
    posted to drug_design by ramensky on 2008-03-23 17:44:14 as ** along with 3 people operon nicklynch junehlee
  • A systematic method for identifying small-molecule modulators of protein-protein interactions
    Proceedings of the National Academy of Sciences, Vol. 101, No. 44. (2 November 2004), pp. 15591-15596.
    by Alexander R Horswill, Sergey N Savinov, Stephen J Benkovic
    posted to drug_design protein-protein by ramensky on 2008-03-18 12:09:42 as ** along with 1 person higueruelo
  • Human Genetics: Variants in common diseases
    Nature (11 February 2007)
    by Nelson B Freimer, Chiara Sabatti
    posted to association_studies by ramensky on 2008-03-18 11:54:25 as ** along with 1 person jd222
  • The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology.
    Nat Genet, Vol. 36, No. 10. (October 2004), pp. 1045-1051.
    by N Freimer, C Sabatti
    posted to association_studies by ramensky on 2008-03-18 11:53:55 as **
  • Two sources of the Russian patrilineal heritage in their Eurasian context.
    Am J Hum Genet, Vol. 82, No. 1. (January 2008), pp. 236-250.
    by O Balanovsky, S Rootsi, A Pshenichnov, T Kivisild, M Churnosov, I Evseeva, E Pocheshkhova, M Boldyreva, N Yankovsky, E Balanovska, R Villems
    posted to evolution haplotypes by ramensky on 2008-03-18 09:44:05 as ** along with 2 people Archaeogenetics ArtemPankin
  • Computer prediction of drug resistance mutations in proteins
    Drug Discovery Today, Vol. 10, No. 7. (1 April 2005), pp. 521-529.
    by Zhi W Cao, Lian Y Han, Chan J Zheng, Zhi L Ji, Xin Chen, Hong H Lin, Yu Z Chen
    posted to adaptation drug_design mutations by ramensky on 2008-03-17 15:25:46 as ** along with 2 people and 2 groups barry nedwards structural_bioinformatics Bioinformatics
  • Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness.
    Nat Med, Vol. 10, No. 10. (October 2004), pp. 1117-1121.
    by T Cohen, M Murray
    posted to adaptation drug_design by ramensky on 2008-03-12 13:01:20 as **
  • Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.
    Am J Hum Genet, Vol. 82, No. 1. (January 2008), pp. 100-112.
    by IP Gorlov, OY Gorlova, SR Sunyaev, MR Spitz, CI Amos
    posted to nssnps association_studies by ramensky on 2008-03-08 23:48:12 as ** along with 1 person jyuh
  • Assessing the function of genetic variants in candidate gene association studies
    Nat Rev Genet, Vol. 5, No. 8. (2004), pp. 589-597.
    by Timothy R Rebbeck, Margaret Spitz, Xifeng Wu
    posted to association_studies nssnps by ramensky on 2008-03-08 23:42:37 as ** along with 1 person raiyar
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