Parkinson's disease and pesticides: a toxicological perspective

@article{citeulike:2861866, abstract = {Environmental factors have been shown to contribute to the incidence of Parkinson's disease (PD). Pesticides, which represent one of the primary classes of environmental agents associated with PD, share the common feature of being intentionally released into the environment to control or eliminate pests. Pesticides consist of multiple classes and subclasses of insecticides, herbicides, rodenticides, fungicides, fumigants and others and exhibit a vast array of chemically diverse structures. In this review we examine the evidence regarding the ability of each of the major pesticide subclasses to increase the incidence of PD. We propose that, from a toxicological perspective, it would be beneficial to identify specific subclasses, common structural features and the propensity for widespread human exposure when considering the potential role in PD, rather than using the overly broad term of [`]pesticides' to describe this diverse group of chemicals. Furthermore, these chemicals and their environmentally relevant combinations should be evaluated for their ability to promote or accelerate PD and not merely for being singular causative agents.}, author = {Hatcher, Jaime M. and Pennell, Kurt D. and Miller, Gary W. }, citeulike-article-id = {2861866}, doi = {10.1016/j.tips.2008.03.007}, journal = {Trends in Pharmacological Sciences}, keywords = {2008, parkinsons, pesticides}, month = {June}, number = {6}, pages = {322--329}, posted-at = {2008-06-04 17:54:59}, priority = {2}, title = {Parkinson's disease and pesticides: a toxicological perspective}, url = {http://dx.doi.org/10.1016/j.tips.2008.03.007}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:2861866 L3 - citeulike-article-id:2861866 TI - Parkinson's disease and pesticides: a toxicological perspective JF - Trends in Pharmacological Sciences VL - 29 IS - 6 SP - 322 EP - 329 N2 - Environmental factors have been shown to contribute to the incidence of Parkinson's disease (PD). Pesticides, which represent one of the primary classes of environmental agents associated with PD, share the common feature of being intentionally released into the environment to control or eliminate pests. Pesticides consist of multiple classes and subclasses of insecticides, herbicides, rodenticides, fungicides, fumigants and others and exhibit a vast array of chemically diverse structures. In this review we examine the evidence regarding the ability of each of the major pesticide subclasses to increase the incidence of PD. We propose that, from a toxicological perspective, it would be beneficial to identify specific subclasses, common structural features and the propensity for widespread human exposure when considering the potential role in PD, rather than using the overly broad term of [`]pesticides' to describe this diverse group of chemicals. Furthermore, these chemicals and their environmentally relevant combinations should be evaluated for their ability to promote or accelerate PD and not merely for being singular causative agents. KW - 2008 KW - parkinsons KW - pesticides AU - Hatcher, Jaime AU - Pennell, Kurt AU - Miller, Gary PY - 2008/06// UR - http://dx.doi.org/10.1016/j.tips.2008.03.007 ER -