GridCell: a stochastic particle-based biological system simulator

@article{citeulike:3038108, abstract = {BACKGROUND:Realistic biochemical simulators aim to improve our understanding of many biological processes that would be otherwise very difficult to monitor in experimental studies. Increasingly accurate simulators may provide insights into the regulation of biological processes due to stochastic or spatial effects.RESULTS:We have developed GridCell as a three-dimensional simulation environment for investigating the behaviour of biochemical networks under a variety of spatial influences including crowding, recruitment and localization. GridCell enables the tracking and characterization of individual particles, leading to insights on the behaviour of low copy number molecules participating in signaling networks. The simulation space is divided into a discrete 3D grid which provides ideal support for particle collisions without distance calculation and particle search. SBML support enables existing networks to be simulated and visualized. The user interface provides intuitive navigation that facilitates insights into species behaviour across spatial and temporal dimensions. We demonstrate the effect of crowing on a Michaelis-Menten system.CONCLUSIONS:GridCell is an effective stochastic particle simulator designed to track the progress of individual particles in a three-dimensional space. Spatial influences such as crowding, co-localization and recruitment may be investigated.}, author = {Boulianne, Laurier and Assaad, Sevin A. and Dumontier, Michel and Gross, Warren }, citeulike-article-id = {3038108}, doi = {http://dx.doi.org/10.1186/1752-0509-2-66}, journal = {BMC Systems Biology}, keywords = {simulation}, number = {1}, posted-at = {2008-07-24 02:55:24}, priority = {2}, title = {GridCell: a stochastic particle-based biological system simulator}, url = {http://dx.doi.org/10.1186/1752-0509-2-66}, volume = {2}, year = {2008} }

TY - JOUR ID - citeulike:3038108 L3 - citeulike-article-id:3038108 TI - GridCell: a stochastic particle-based biological system simulator JF - BMC Systems Biology VL - 2 IS - 1 N2 - BACKGROUND:Realistic biochemical simulators aim to improve our understanding of many biological processes that would be otherwise very difficult to monitor in experimental studies. Increasingly accurate simulators may provide insights into the regulation of biological processes due to stochastic or spatial effects.RESULTS:We have developed GridCell as a three-dimensional simulation environment for investigating the behaviour of biochemical networks under a variety of spatial influences including crowding, recruitment and localization. GridCell enables the tracking and characterization of individual particles, leading to insights on the behaviour of low copy number molecules participating in signaling networks. The simulation space is divided into a discrete 3D grid which provides ideal support for particle collisions without distance calculation and particle search. SBML support enables existing networks to be simulated and visualized. The user interface provides intuitive navigation that facilitates insights into species behaviour across spatial and temporal dimensions. We demonstrate the effect of crowing on a Michaelis-Menten system.CONCLUSIONS:GridCell is an effective stochastic particle simulator designed to track the progress of individual particles in a three-dimensional space. Spatial influences such as crowding, co-localization and recruitment may be investigated. KW - simulation AU - Boulianne, Laurier AU - Assaad, Sevin AU - Dumontier, Michel AU - Gross, Warren PY - 2008/// UR - http://dx.doi.org/10.1186/1752-0509-2-66 ER -