What stops synchronized thalamocortical oscillations?

@article{citeulike:267645, abstract = {Slow-wave sleep as well as generalized absence seizures are characterized by the occurrence of synchronized oscillations in thalamocortical systems that spontaneously appear and disappear. The spontaneous appearance of synchronized oscillations results from the initiation by one or a small number of cells followed by the progressive recruitment of large numbers of neighboring neurons into the synchronized network activity. Synchronized network oscillations representative of slow-wave sleep, as well as absence seizures, were demonstrated to cease spontaneously at least in part through the persistent activation of a hyperpolarization-activated cation conductance. Block of this conductance resulted in oscillations that, once generalized, occur continuously. These results indicate that the persistent activation of a hyperpolarization-activated cation conductance is a key mechanism through which synchronized oscillations in thalamocortical networks normally terminate.}, address = {Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06473, USA.}, author = {Bal, T. and McCormick, D. A. }, citeulike-article-id = {267645}, issn = {0896-6273}, journal = {Neuron}, keywords = {rythme, thalamocortical, theta}, month = {August}, number = {2}, pages = {297--308}, posted-at = {2005-07-29 13:37:45}, priority = {2}, title = {What stops synchronized thalamocortical oscillations?}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8780653}, volume = {17}, year = {1996} }

TY - JOUR ID - citeulike:267645 L3 - citeulike-article-id:267645 TI - What stops synchronized thalamocortical oscillations? JF - Neuron VL - 17 IS - 2 SP - 297 EP - 308 AD - Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06473, USA. SN - 0896-6273 N2 - Slow-wave sleep as well as generalized absence seizures are characterized by the occurrence of synchronized oscillations in thalamocortical systems that spontaneously appear and disappear. The spontaneous appearance of synchronized oscillations results from the initiation by one or a small number of cells followed by the progressive recruitment of large numbers of neighboring neurons into the synchronized network activity. Synchronized network oscillations representative of slow-wave sleep, as well as absence seizures, were demonstrated to cease spontaneously at least in part through the persistent activation of a hyperpolarization-activated cation conductance. Block of this conductance resulted in oscillations that, once generalized, occur continuously. These results indicate that the persistent activation of a hyperpolarization-activated cation conductance is a key mechanism through which synchronized oscillations in thalamocortical networks normally terminate. KW - rythme KW - thalamocortical KW - theta AU - Bal, T AU - McCormick, DA PY - 1996/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/8780653 ER -