Placebo-induced changes in FMRI in the anticipation and experience of pain.

@article{citeulike:1269346, abstract = {The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain.}, address = {Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA. torw@umich.edu}, author = {Wager, T. D. and Rilling, J. K. and Smith, E. E. and Sokolik, A. and Casey, K. L. and Davidson, R. J. and Kosslyn, S. M. and Rose, R. M. and Cohen, J. D. }, citeulike-article-id = {1269346}, doi = {http://dx.doi.org/10.1126/science.1093065}, issn = {1095-9203}, journal = {Science}, keywords = {anticipation, empathy, fmri, placebo}, month = {February}, number = {5661}, pages = {1162--1167}, posted-at = {2007-05-01 00:48:49}, priority = {2}, title = {Placebo-induced changes in FMRI in the anticipation and experience of pain.}, url = {http://dx.doi.org/10.1126/science.1093065}, volume = {303}, year = {2004} }

TY - JOUR ID - citeulike:1269346 L3 - citeulike-article-id:1269346 TI - Placebo-induced changes in FMRI in the anticipation and experience of pain. JF - Science VL - 303 IS - 5661 SP - 1162 EP - 1167 AD - Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA. torw@umich.edu SN - 1095-9203 N2 - The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain. KW - anticipation KW - empathy KW - fmri KW - placebo AU - Wager, TD AU - Rilling, JK AU - Smith, EE AU - Sokolik, A AU - Casey, KL AU - Davidson, RJ AU - Kosslyn, SM AU - Rose, RM AU - Cohen, JD PY - 2004/02/20/ UR - http://dx.doi.org/10.1126/science.1093065 ER -