Distinguishing Whether Dopamine Regulates Liking, Wanting, and/or Learning About Rewards.

by: S Robinson, SM Sandstrom, VH Denenberg, RD Palmiter

Behav Neurosci, Vol. 119, No. 1. (February 2005), pp. 5-15.

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Abstract

To determine whether dopamine regulates liking, wanting, and/or learning about rewards during goal-directed behavior, the authors tested genetically engineered dopamine-deficient (DD) mice for acquisition of an appetitive T-maze task with and without endogenous dopamine signaling. Experiment 1 established that DD mice treated with L-dihydroxyphenylalanine (L-dopa [LD]) perform similarly to controls on a T-maze task designed to measure liking, wanting, and learning about rewards. Experiment 2, which tested saline-, caffeine-, and LD-treated DD mice on the T maze, separated performance factors from cognitive processes and revealed that dopamine is not necessary for mice to like or learn about rewards but is necessary for mice to seek (want) rewards during goal-directed behavior. ((c) 2005 APA, all rights reserved).

@article{citeulike:126746, abstract = {To determine whether dopamine regulates liking, wanting, and/or learning about rewards during goal-directed behavior, the authors tested genetically engineered dopamine-deficient (DD) mice for acquisition of an appetitive T-maze task with and without endogenous dopamine signaling. Experiment 1 established that DD mice treated with L-dihydroxyphenylalanine (L-dopa [LD]) perform similarly to controls on a T-maze task designed to measure liking, wanting, and learning about rewards. Experiment 2, which tested saline-, caffeine-, and LD-treated DD mice on the T maze, separated performance factors from cognitive processes and revealed that dopamine is not necessary for mice to like or learn about rewards but is necessary for mice to seek (want) rewards during goal-directed behavior. ((c) 2005 APA, all rights reserved).}, address = {Neurobiology and Behavior Program, University of Washington, Seattle, WA, US.}, author = {Robinson, S. and Sandstrom, S. M. and Denenberg, V. H. and Palmiter, R. D. }, citeulike-article-id = {126746}, doi = {http://dx.doi.org/10.1037/0735-7044.119.1.5}, issn = {0735-7044}, journal = {Behav Neurosci}, keywords = {caffeine, decision-making, dopamine, learning, mice, reinforcement, reward}, month = {February}, number = {1}, pages = {5--15}, posted-at = {2005-03-14 18:23:14}, priority = {3}, title = {Distinguishing Whether Dopamine Regulates Liking, Wanting, and/or Learning About Rewards.}, url = {http://dx.doi.org/10.1037/0735-7044.119.1.5}, volume = {119}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:126746 L3 - citeulike-article-id:126746 TI - Distinguishing Whether Dopamine Regulates Liking, Wanting, and/or Learning About Rewards. JF - Behav Neurosci VL - 119 IS - 1 SP - 5 EP - 15 AD - Neurobiology and Behavior Program, University of Washington, Seattle, WA, US. SN - 0735-7044 N2 - To determine whether dopamine regulates liking, wanting, and/or learning about rewards during goal-directed behavior, the authors tested genetically engineered dopamine-deficient (DD) mice for acquisition of an appetitive T-maze task with and without endogenous dopamine signaling. Experiment 1 established that DD mice treated with L-dihydroxyphenylalanine (L-dopa [LD]) perform similarly to controls on a T-maze task designed to measure liking, wanting, and learning about rewards. Experiment 2, which tested saline-, caffeine-, and LD-treated DD mice on the T maze, separated performance factors from cognitive processes and revealed that dopamine is not necessary for mice to like or learn about rewards but is necessary for mice to seek (want) rewards during goal-directed behavior. ((c) 2005 APA, all rights reserved). KW - caffeine KW - decision-making KW - dopamine KW - learning KW - mice KW - reinforcement KW - reward AU - Robinson, S AU - Sandstrom, SM AU - Denenberg, VH AU - Palmiter, RD PY - 2005/02// UR - http://dx.doi.org/10.1037/0735-7044.119.1.5 ER -

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