A trial-based experimental design for fMRI.

@article{citeulike:1224466, abstract = {An experimental design for functional MRI (fMRI) is presented whose conceptual units of analysis are behavioral trials, in contrast to blocks of trials. This type of design is referred to as a trial-based (TB) fMRI design. It is explained how TB designs can afford the ability to: (1) randomize the presentation of behavioral trials and (2) utilize intertrial variance in uncontrolled behavioral measures to examine their functional correlates. A particular type of TB design that involves modeling trial-evoked fMRI responses with one or more shifted impulse response functions is described. This design is capable of discriminating functional changes occurring during temporally separated behavioral subcomponents within trials. An example of such a design is implemented and its statistical specificity, functional sensitivity, and functional specificity are tested.}, address = {Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.}, author = {Zarahn, E. and Aguirre, G. and D'Esposito, M. }, citeulike-article-id = {1224466}, doi = {http://dx.doi.org/10.1006/nimg.1997.0279}, issn = {1053-8119}, journal = {Neuroimage}, keywords = {fmri\_methods, trial-based}, month = {August}, number = {2}, pages = {122--138}, posted-at = {2007-04-13 19:09:15}, priority = {5}, title = {A trial-based experimental design for fMRI.}, url = {http://dx.doi.org/10.1006/nimg.1997.0279}, volume = {6}, year = {1997} }

TY - JOUR ID - citeulike:1224466 L3 - citeulike-article-id:1224466 TI - A trial-based experimental design for fMRI. JF - Neuroimage VL - 6 IS - 2 SP - 122 EP - 138 AD - Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA. SN - 1053-8119 N2 - An experimental design for functional MRI (fMRI) is presented whose conceptual units of analysis are behavioral trials, in contrast to blocks of trials. This type of design is referred to as a trial-based (TB) fMRI design. It is explained how TB designs can afford the ability to: (1) randomize the presentation of behavioral trials and (2) utilize intertrial variance in uncontrolled behavioral measures to examine their functional correlates. A particular type of TB design that involves modeling trial-evoked fMRI responses with one or more shifted impulse response functions is described. This design is capable of discriminating functional changes occurring during temporally separated behavioral subcomponents within trials. An example of such a design is implemented and its statistical specificity, functional sensitivity, and functional specificity are tested. KW - fmri_methods KW - trial-based AU - Zarahn, E AU - Aguirre, G AU - D'Esposito, M PY - 1997/08// UR - http://dx.doi.org/10.1006/nimg.1997.0279 ER -